Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 7/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 3/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7068721 | 0.94 | MAOA (0.51) | MAOAKEAP1SMN1; SMN2MAOBDPP7 | |
| SCHEMBL4421772 | 0.86 | — | — | |
| Hydrochloric Acid SCHEMBL7219443 | 0.84 | MAOA (0.48) | MAOAMAOBDPP7SIGMAR1 | |
| SCHEMBL12677450 | 0.84 | — | — | |
| SCHEMBL1098438 | 0.78 | MAOA (0.53) | MAOAMAOB | |
| SCHEMBL1099182 | 0.78 | MAOA (0.53) | MAOAMAOBDPP7 | |
| SCHEMBL1099184 | 0.78 | MAOA (0.53) | MAOAMAOBDPP7 | |
| SCHEMBL8169120 | 0.78 | MAOA (0.53) | MAOAMAOBSIGMAR1 | |
| SCHEMBL7235805 | 0.78 | MAOA (0.53) | MAOAMAOB | |
| SCHEMBL7066686 | 0.78 | MAOA (0.53) | MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003047583-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING BENZOFURANYL SUBSTITUTED 3-CYANOQUINOLINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SOLID TUMOURS | ASTRAZENECA AB (SE) | 2003-06-12 | — | — | WO | disclosed |
| WO-2003047585-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING BENZOFURANYL SUBSTITUTED 3-CYANOQUINOLINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SOLID TUMOURS | ASTRAZENECA AB (SE) | 2003-06-12 | — | — | WO | disclosed |
| WO-2003047584-A1 | QUINOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-06-12 | — | — | WO | disclosed |