Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 8/20 | 0.73 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.73 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.73 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.73 |
| ▸ | F11 | P03951 | 16/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | PLG | P00747 | 1/20 | 0.56 |
| ▸ | PLAU | P00749 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7066980 | 1.00 | KLKB1 (0.73) | KLKB1PRSS1PRSS2PRSS3F11 | |
| Hydrochloric Acid SCHEMBL19988159 | 0.99 | KLKB1 (0.72) | KLKB1PRSS1PRSS2PRSS3F11 | |
| Hydrochloric Acid SCHEMBL14159640 | 0.99 | KLKB1 (0.72) | KLKB1PRSS1PRSS2PRSS3F11 | |
| Hydrochloric Acid SCHEMBL14159641 | 0.99 | KLKB1 (0.72) | KLKB1PRSS1PRSS2PRSS3F11 | |
| Hydrochloric Acid SCHEMBL19988160 | 0.99 | KLKB1 (0.72) | KLKB1PRSS1PRSS2PRSS3F11 | |
| Aminobenzoic Acid SCHEMBL7267215 | 0.88 | KLKB1 (0.62) | KLKB1PRSS1PRSS2PRSS3F11 | |
| Hydrochloric Acid SCHEMBL7268849 | 0.87 | KLKB1 (0.60) | KLKB1PRSS1PRSS2PRSS3F11 | |
| SCHEMBL6450462 | 0.87 | KLKB1 (0.74) | KLKB1PRSS1PRSS2PRSS3F11 | |
| SCHEMBL5961152 | 0.87 | KLKB1 (0.74) | KLKB1PRSS1PRSS2PRSS3F11 | |
| Hydrochloric Acid SCHEMBL7266461 | 0.87 | KLKB1 (0.60) | KLKB1PRSS1PRSS2PRSS3F11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-9048817-A | — | — | None | — | — | JP | disclosed |
| US-6740647-B1 | AMIDINES AND HYDROXYAMIDINE DERIVATIVES | ABBOTT GMBH & CO., KG (DE) | 2004-05-25 | — | — | US | disclosed |
| US-6440937-B1 | COMPETITIVE INHIBITORS OF TRYPSIN-LIKE SERIN PROTEASES, ESPECIALLY THROMBIN AND KININOGENASES SUCH AS KALLIKREIN; THROMBIN INHIBITORS, ANTICOAGULANTS, AND ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES | 2002-08-27 | — | — | US | disclosed |
| US-6114358-A | Thrombin inhibitors | BASF AKTIENGESELLSCHAFT (DE) | 2000-09-05 | — | — | US | disclosed |
| JP-H0948817-A | AFFINITY RESIN FOR PURIFICATION OF PLASMA KALLIKREIN | MITSUBISHI CHEM CORP | 1997-02-18 | — | — | JP | disclosed |