Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 2/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | TPH1 | P17752 | 2/20 | 0.36 |
| ▸ | TPH2 | Q8IWU9 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6088074 | 0.99 | GRIN1 (0.39) | GRIN1GRIN2BTPH1TPH2MEN1 | |
| SCHEMBL6087285 | 0.98 | GRIN1 (0.39) | GRIN1GRIN2BTPH1TPH2MEN1 | |
| SCHEMBL6087020 | 0.95 | GRIN1 (0.43) | GRIN1GRIN2BTPH1TPH2MEN1 | |
| SCHEMBL7841353 | 0.91 | GRIN1 (0.34) | GRIN1GRIN2BTPH1TPH2MEN1 | |
| SCHEMBL7066678 | 0.89 | HPGD (0.40) | GRIN1GRIN2BMEN1KMT2ATDP1 | |
| SCHEMBL675478 | 0.89 | KMT2A (0.35) | GRIN1GRIN2BMEN1KMT2ATDP1 | |
| SCHEMBL7849809 | 0.87 | GRIN1 (0.38) | GRIN1GRIN2BTPH1TPH2MEN1 | |
| SCHEMBL6086536 | 0.85 | KMT2A (0.36) | GRIN1GRIN2BMEN1KMT2ATDP1 | |
| SCHEMBL7068410 | 0.84 | GRIN1 (0.38) | GRIN1GRIN2BTPH1TPH2MEN1 | |
| SCHEMBL6086562 | 0.84 | MTOR (0.38) | GRIN1GRIN2BTPH1TPH2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0827498-B1 | NEW ANTIVIRAL SUBSTITUTED PYRIMIDINEDIONE HOMOCARBOCYCLIC NUCLEOSIDE DERIVATIVES AND METHODS FOR THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME AS ACTIVE INGREDIENTS | SAMJIN PHARM CO LTD (KR) | 2003-06-18 | — | — | EP | disclosed |
| US-5922727-A | 1-((SUBSTITUTED)CYCLOALK(EN)YLALKYL)-6-((SUB)PHENYL(CARBONYL, SULFIDE, OR OXO))-2,4-PYRIMIDINEDIONE DERIVATIVES HAVING SUPERIOR ANTIVIRAL ACTIVITIES; HIV | SAMJIN PHARMACEUTICAL CO., LTD (KR) | 1999-07-13 | — | — | US | disclosed |