Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 18/20 | 0.58 |
| ▸ | KDR | P35968 | 13/20 | 0.58 |
| ▸ | EGFR | P00533 | 3/20 | 0.58 |
| ▸ | LCK | P06239 | 2/20 | 0.58 |
| ▸ | YES1 | P07947 | 2/20 | 0.58 |
| ▸ | CSK | P41240 | 2/20 | 0.58 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.58 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.58 |
| ▸ | GAK | O14976 | 1/20 | 0.58 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.58 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.58 |
| ▸ | STK10 | O94804 | 1/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.58 |
| ▸ | FYN | P06241 | 1/20 | 0.58 |
| ▸ | LYN | P07948 | 1/20 | 0.58 |
| ▸ | RET | P07949 | 1/20 | 0.58 |
| ▸ | HCK | P08631 | 1/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.58 |
| ▸ | FGR | P09769 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7069374 | 0.95 | SRC (0.56) | SRCKDREGFRLCKYES1 | |
| SCHEMBL7068269 | 0.90 | SRC (0.58) | SRCKDREGFRLCKYES1 | |
| SCHEMBL7068724 | 0.89 | SRC (0.51) | SRCKDREGFRLCKYES1 | |
| SCHEMBL3674086 | 0.87 | SRC (0.75) | SRCKDREGFRLCKYES1 | |
| SCHEMBL7068171 | 0.86 | SRC (0.53) | SRCKDREGFRLCKYES1 | |
| SCHEMBL7069410 | 0.85 | SRC (0.54) | SRCKDREGFRLCKYES1 | |
| SCHEMBL7065783 | 0.84 | SRC (0.48) | SRCKDREGFRLCKYES1 | |
| SCHEMBL3679556 | 0.83 | SRC (0.75) | SRCKDREGFRLCKYES1 | |
| SCHEMBL3670927 | 0.81 | SRC (0.74) | SRCKDREGFRLCKYES1 | |
| SCHEMBL3677472 | 0.81 | SRC (0.73) | SRCKDREGFRLCKYES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003047585-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING BENZOFURANYL SUBSTITUTED 3-CYANOQUINOLINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SOLID TUMOURS | ASTRAZENECA AB (SE) | 2003-06-12 | — | — | WO | disclosed |