Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 14/20 | 0.48 |
| ▸ | KDR | P35968 | 8/20 | 0.47 |
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.45 |
| ▸ | EGFR | P00533 | 3/20 | 0.45 |
| ▸ | LCK | P06239 | 2/20 | 0.45 |
| ▸ | YES1 | P07947 | 2/20 | 0.45 |
| ▸ | CSK | P41240 | 2/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.44 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.44 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
| ▸ | STK10 | O94804 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | LYN | P07948 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7068724 | 0.95 | SRC (0.51) | SRCKDREGFRLCKYES1 | |
| SCHEMBL7068171 | 0.92 | SRC (0.53) | SRCKDRTBK1EGFRLCK | |
| SCHEMBL7069374 | 0.89 | SRC (0.56) | SRCKDRTBK1EGFRLCK | |
| SCHEMBL7067557 | 0.88 | SRC (0.50) | SRCKDRTBK1EGFRLCK | |
| SCHEMBL7069103 | 0.87 | MAP3K8 (0.37) | SRCKDRTBK1EGFRLCK | |
| SCHEMBL7067679 | 0.84 | SRC (0.58) | SRCKDREGFRLCKYES1 | |
| SCHEMBL7069410 | 0.84 | SRC (0.54) | SRCKDRTBK1EGFRLCK | |
| SCHEMBL7069001 | 0.84 | IKBKE (0.38) | SRCKDRTBK1EGFRLCK | |
| SCHEMBL7068176 | 0.83 | SRC (0.52) | SRCKDREGFRMAP2K1ABL1 | |
| SCHEMBL3677472 | 0.80 | SRC (0.73) | SRCKDREGFRLCKYES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003047584-A1 | QUINOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-06-12 | — | — | WO | disclosed |
| WO-2003047585-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING BENZOFURANYL SUBSTITUTED 3-CYANOQUINOLINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SOLID TUMOURS | ASTRAZENECA AB (SE) | 2003-06-12 | — | — | WO | disclosed |