SCHEMBL7068337

SCHEMBL7068337

BrCCCOc1ccc2cccnc2c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.59
PDE10A Q9Y233 1/20 0.56
HTT P42858 2/20 0.50
CYP1A2 P05177 2/20 0.50
CYP2C19 P33261 2/20 0.50
MAPT P10636 3/20 0.47
NPC1 O15118 2/20 0.47
RAB9A P51151 2/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
DRD3 P35462 1/20 0.47
TDP1 Q9NUW8 2/20 0.47
ALDH1A1 P00352 3/20 0.46
MEN1 O00255 1/20 0.46
CASP1 P29466 1/20 0.46
CASP7 P55210 1/20 0.46
KMT2A Q03164 1/20 0.46
NR4A2 P43354 1/20 0.46
NCF1 P14598 3/20 0.43
KDM4E B2RXH2 2/20 0.42
MAPK1 P28482 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29133435 0.95 PDE10A (0.58) CYP3A4PDE10AHTTCYP1A2CYP2C19
SCHEMBL14464160 0.92 CYP3A4 (0.60) CYP3A4PDE10AHTTCYP1A2CYP2C19
SCHEMBL23412137 0.88 CYP3A4 (0.68) CYP3A4PDE10AHTTCYP1A2CYP2C19
SCHEMBL5398136 0.87 PPARG (0.50) CYP3A4PDE10AHTTCYP1A2CYP2C19
SCHEMBL23412263 0.86 NPC1 (0.68) CYP3A4PDE10AHTTCYP1A2CYP2C19
SCHEMBL12957491 0.85 CYP3A4 (0.60) CYP3A4PDE10AHTTCYP1A2CYP2C19
SCHEMBL27976043 0.85 CYP3A4 (0.64) CYP3A4PDE10AHTTCYP1A2CYP2C19
SCHEMBL32667931 0.84 PDE10A (0.60) CYP3A4PDE10AHTTCYP1A2CYP2C19
SCHEMBL5957137 0.84 CYP3A4 (0.59) CYP3A4PDE10AHTTCYP1A2CYP2C19
SCHEMBL23412359 0.83 TDP1 (0.62) CYP3A4PDE10AHTTCYP1A2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023143393-A1 TRICYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF 上海科技大学 2023-08-03 WO disclosed
WO-2003047583-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING BENZOFURANYL SUBSTITUTED 3-CYANOQUINOLINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SOLID TUMOURS ASTRAZENECA AB (SE) 2003-06-12 WO disclosed
WO-2003048159-A1 QUINOLINE DERIVATIVES ASTRAZENECA AB (SE) 2003-06-12 WO disclosed
EP-0658160-A1 ANTIPSYCHOTIC QUINOLINE DERIVATIVES OF BENZODIOXANMETHYLAMINE AMERICAN HOME PRODUCTS CORPORATION (US) 1995-06-21 EP disclosed
WO-1994005655-A1 ANTIPSYCHOTIC QUINOLINE DERIVATIVES OF BENZODIOXANMETHYLAMINE AMERICAN HOME PRODUCTS CORPORATION (US) 1994-03-17 WO disclosed
US-5235055-A Antipsychotic quinoline derivatives of benzodioxanmethylamine AMERICAN HOME PRODUCTS CORPORATION (US) 1993-08-10 US disclosed