SCHEMBL7068542

SCHEMBL7068542

N=C(N)c1cccc(N2CC(COc3ccc4c(c3)OCO4)OC2=O)c1

nearest known ligand 0.50

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GRM2 Q14416 16/20 0.50
SIGMAR1 Q99720 4/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7068128 0.90 SIGMAR1 (0.51) GRM2SIGMAR1
SCHEMBL7389228 0.88 GRM2 (0.60) GRM2
SCHEMBL7387746 0.87 GRM2 (0.59) GRM2
SCHEMBL7067345 0.86 GRM2 (0.55) GRM2
SCHEMBL7066362 0.85 GRM2 (0.46) GRM2SIGMAR1
SCHEMBL7064629 0.84 GRM2 (0.64) GRM2
SCHEMBL2823357 0.84 GRM2 (0.70) GRM2SIGMAR1
SCHEMBL7067364 0.84 GRM2 (0.64) GRM2
SCHEMBL7064636 0.84 GRM2 (0.60) GRM2
SCHEMBL7067648 0.83 GRM2 (0.55) GRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2003047572-A1 USE OF 1-PHENYL-OXAZOLIDINE-2-ONE COMPOUNDS AS PROTEASE M INHIBITORS MERCK PATENT GMBH (DE) 2003-06-12 WO claimed
WO-2003047572-A1 USE OF 1-PHENYL-OXAZOLIDINE-2-ONE COMPOUNDS AS PROTEASE M INHIBITORS MERCK PATENT GMBH (DE) 2003-06-12 WO disclosed