Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 2/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.41 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.38 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 2/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6936636 | 0.85 | TRPV1 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL10719795 | 0.70 | PSEN1 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6932378 | 0.69 | CNR2 (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL31231454 | 0.68 | TRPV1 (0.47) | CNR2ALDH1A1 | |
| SCHEMBL10720538 | 0.64 | KMT2A (0.41) | ALDH1A1HCRTR2 | |
| SCHEMBL6559509 | 0.64 | TRPV1 (0.45) | ALDH1A1 | |
| SCHEMBL21316483 | 0.63 | FAAH (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL22363303 | 0.63 | FAAH (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1679043 | 0.63 | FAAH (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5069785 | 0.63 | PSEN1 (0.92) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915087-B1 | Sulfonamide substituted fused five-membered ring compounds, their use as medicaments as well as pharmaceutical compositions containing them | AVENTIS PHARMA GMBH (DE) | 2003-04-02 | — | — | EP | disclosed |