⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10904062 | 0.82 | — | — | |
| SCHEMBL1683755 | 0.76 | — | — | |
| SCHEMBL22208391 | 0.74 | — | — | |
| SCHEMBL31406724 | 0.72 | — | — | |
| SCHEMBL18137507 | 0.72 | — | — | |
| SCHEMBL15062282 | 0.67 | — | — | |
| SCHEMBL7634919 | 0.67 | — | — | |
| SCHEMBL18930034 | 0.66 | — | — | |
| SCHEMBL3199056 | 0.66 | PREP (0.31) | — | |
| SCHEMBL15020363 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160367693-A1 | Selective Arylation of Dichalcogenides in Biomolecules | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-12-22 | — | — | US | disclosed |
| US-8980938-B2 | CXCR2 inhibitors | SANOFI (FR) | 2015-03-17 | — | — | US | disclosed |
| EP-2416777-B1 | THERAPEUTIC APPLICATIONS IN THE CARDIOVASCULAR FIELD OF QUINAZOLINEDIONE DERIVATIVES | SANOFI SA (FR) | 2014-11-12 | — | — | EP | disclosed |
| US-8642643-B2 | CXCR2 antagonists | SANOFI (FR) | 2014-02-04 | — | — | US | disclosed |
| US-20090258936-A1 | CXCR2 INHIBITORS | SANOFI-AVENTIS (FR) | 2009-10-15 | — | — | US | disclosed |
| US-20090258906-A1 | CXCR2 ANTAGONISTS | SANOFI-AVENTIS (FR) | 2009-10-15 | — | — | US | disclosed |
| US-6518299-B1 | Trans-5-(1-Acetylamino-2-ethyl)butyl-1 -aminoiminomethylpyrrolidine-3-carboxylic acid | BIOCRYST PHARMACEUTICALS, INC. | 2003-02-11 | — | — | US | disclosed |