Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CLK1 | P49759 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.45 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NQO1 | P15559 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19889941 | 0.78 | KDM4E (0.60) | KDM4EMAPTCLK1CDK2NPSR1 | |
| SCHEMBL12285138 | 0.71 | KDM4E (0.55) | KDM4ECLK1ALDH1A1MEN1KMT2A | |
| SCHEMBL6529865 | 0.69 | PDE10A (0.50) | KDM4EABCC8KCNJ11ALDH1A1KMT2A | |
| SCHEMBL24373484 | 0.69 | KDM4E (0.58) | KDM4EMAPTCLK1CDK2NPSR1 | |
| SCHEMBL30774249 | 0.69 | KDM4E (0.58) | KDM4EMAPTCLK1CDK2NPSR1 | |
| SCHEMBL3272746 | 0.69 | SRC (0.60) | KDM4ENPSR1NQO1HPGDSSRC | |
| SCHEMBL12068376 | 0.69 | KDM4E (1.00) | KDM4EMAPTCLK1CDK2NPSR1 | |
| SCHEMBL15647921 | 0.68 | KDM4E (0.44) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL19610551 | 0.68 | NQO1 (0.58) | KDM4EMAPTCLK1CDK2NPSR1 | |
| SCHEMBL19889997 | 0.68 | KDM4E (0.56) | KDM4EMAPTCLK1CDK2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003047582-A1 | QUINOLINE DERIVATIVES AS ANTITUMOUR AGENTS | ASTRAZENECA AB (SE) | 2003-06-12 | — | — | WO | disclosed |