Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 15/20 | 0.70 |
| ▸ | CXCR1 | P25024 | 7/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | ALB | P02768 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | TSPO | P30536 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5499098 | 0.82 | CXCR2 (0.76) | CXCR2CXCR1ALDH1A1KMT2AMEN1 | |
| SCHEMBL6824309 | 0.82 | CXCR2 (1.00) | CXCR2CXCR1ALDH1A1GAAKMT2A | |
| SCHEMBL3705632 | 0.82 | CXCR2 (1.00) | CXCR2CXCR1ALDH1A1GAAKMT2A | |
| SCHEMBL6129920 | 0.81 | CXCR2 (0.66) | CXCR2CXCR1ALDH1A1KMT2AMEN1 | |
| SCHEMBL6104757 | 0.80 | CXCR2 (1.00) | CXCR2CXCR1 | |
| SCHEMBL6817696 | 0.79 | CXCR2 (0.70) | CXCR2CXCR1ALDH1A1KDM4EGAA | |
| SCHEMBL6817693 | 0.79 | CXCR2 (0.70) | CXCR2CXCR1ALDH1A1KDM4EGAA | |
| SCHEMBL7067490 | 0.78 | CXCR2 (0.48) | CXCR2CXCR1ALDH1A1KDM4EGAA | |
| SCHEMBL6929820 | 0.77 | CXCR2 (0.60) | CXCR2CXCR1ALDH1A1KMT2AMEN1 | |
| SCHEMBL7069156 | 0.77 | CXCR2 (0.56) | CXCR2CXCR1ALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1265905-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-03-12 | — | — | EP | disclosed |
| EP-1265905-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-12-18 | — | — | EP | disclosed |
| WO-2001064691-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-09-07 | — | — | WO | disclosed |