Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 2/20 | 0.48 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.48 |
| ▸ | AR | P10275 | 3/20 | 0.46 |
| ▸ | EGFR | P00533 | 3/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 2/20 | 0.38 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6129921 | 0.83 | CXCR2 (0.47) | CXCR2CXCR1AREGFRERBB2 | |
| SCHEMBL6930050 | 0.80 | CXCR2 (0.44) | CXCR2CXCR1AREGFRERBB2 | |
| SCHEMBL8976050 | 0.79 | ALDH1A1 (0.54) | KDM4EMAPTALDH1A1GAA | |
| SCHEMBL7067489 | 0.79 | AR (0.42) | CXCR2CXCR1AREGFRERBB2 | |
| SCHEMBL7097897 | 0.78 | CXCR2 (0.42) | CXCR2CXCR1AREGFRERBB2 | |
| SCHEMBL7069157 | 0.78 | CXCR2 (0.70) | CXCR2CXCR1KDM4EALDH1A1GAA | |
| SCHEMBL22954626 | 0.75 | LRRK2 (0.54) | ARLRRK2ACLYEGLN2IDH1 | |
| SCHEMBL364484 | 0.74 | AR (0.51) | AREGLN2KDM4EMAPTALDH1A1 | |
| SCHEMBL30376409 | 0.74 | AR (0.51) | AREGLN2KDM4EMAPTALDH1A1 | |
| SCHEMBL6930935 | 0.72 | AR (0.37) | CXCR2CXCR1AREGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1265905-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-03-12 | — | — | EP | disclosed |
| EP-1265905-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-12-18 | — | — | EP | disclosed |
| WO-2001064691-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-09-07 | — | — | WO | disclosed |