Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.86 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.86 |
| ▸ | LMNA | P02545 | 3/20 | 0.86 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.86 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.86 |
| ▸ | ACHE | P22303 | 4/20 | 0.41 |
| ▸ | APEX1 | P27695 | 3/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.38 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL15322783 | 1.00 | MEN1 (0.86) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL15324005 | 1.00 | MEN1 (0.86) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL15322406 | 1.00 | MEN1 (0.86) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL15323716 | 1.00 | MEN1 (0.86) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL339837 | 1.00 | — | — | |
| Choline SCHEMBL3721803 | 1.00 | MEN1 (0.86) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL8740332 | 1.00 | MEN1 (0.86) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL326079 | 1.00 | — | — | |
| Choline SCHEMBL8714154 | 1.00 | MEN1 (0.86) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL9543255 | 1.00 | MEN1 (0.86) | MEN1KMT2ALMNACYP3A4SLC5A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230383051-A1 | BIODEGRADABLE THERMOPLASTIC MATERIALS | DIZOLV, INC. | 2023-11-30 | — | — | US | disclosed |
| WO-2022074280-A1 | METHOD FOR MEASURING OXIDATION PARAMETERS OF AN ORGANIC SAMPLE | BIOQUOCHEM, S.L. (ES) | 2022-04-14 | — | — | WO | disclosed |
| CN-110302248-A | The method for extracting Chinese toon seed general flavone | 阜阳师范学院 | 2019-10-08 | — | — | CN | disclosed |
| CN-110236001-A | A kind of biological feed additive improving herbvore jenny reproductive performance | 博益德（北京）生物科技有限公司 | 2019-09-17 | — | — | CN | disclosed |
| CN-105331659-B | Improved cell culture medium | 诺华股份有限公司 | 2019-07-16 | — | — | CN | disclosed |
| CN-105754114-B | A kind of method of eutectic ionic liquid separation and Extraction straw lignin | 南京林业大学 | 2018-09-28 | — | — | CN | disclosed |
| CN-107027753-A | One kind compounding conditioning agent and its application | 安阳市小康农药有限责任公司 | 2017-08-11 | — | — | CN | disclosed |
| CN-101912073-A | Nutrient feed and feeding method for black-boned chickens | UNIV YANGZHOU | 2010-12-15 | — | — | CN | disclosed |
| CN-101897319-A | Feeding method of new broiler hen | UNIV YANGZHOU | 2010-12-01 | — | — | CN | disclosed |
| CN-101715888-A | Total mixed diet granulated feed for meat sheep and preparation method thereof | UNIV YANGZHOU | 2010-06-02 | — | — | CN | disclosed |
| EP-1324979-A2 | IONIC LIQUIDS AND THEIR USE AS SOLVENTS | Scionix Limited (GB) | 2003-07-09 | — | — | EP | disclosed |
| US-6534075-B1 | Antimicrobial and antiviral compositions and treatments for food surfaces | ECOLAB INC. | 2003-03-18 | — | — | US | disclosed |
| WO-2002026701-A2 | IONIC LIQUIDS AND THEIR USE AS SOLVENTS | SCIONIX LIMITED (GB) | 2002-04-04 | — | — | WO | disclosed |
| US-4663278-A | Agglutination dependent enzyme channeling immunoassay | SYVA COMPANY (US) | 1987-05-05 | — | — | US | disclosed |
| US-4629690-A | COMPETITIVE PROTEIN BINDING USING A SECOND ENZYME RELATED TO THE FIRST BY THE PRODUCT OF ONE BEING THE SUBSTRATE OF THE OTHER | SYNTEX (U.S.A.) INC. (US) | 1986-12-16 | — | — | US | disclosed |
| US-4374925-A | PROTEIN BINDING ASSAYS | SYVA COMPANY (US) | 1983-02-22 | — | — | US | disclosed |
| US-4275149-A | IMMUNOASSAY | SYVA COMPANY (US) | 1981-06-23 | — | — | US | disclosed |