SCHEMBL7069294

SCHEMBL7069294

C=CC(=O)OCCC(N)=O

nearest known ligand 0.58

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TSHR P16473 8/20 0.58
ALDH1A1 P00352 5/20 0.58
TP53 P04637 3/20 0.58
HIF1A Q16665 3/20 0.58
CYP3A4 P08684 2/20 0.58
HSD17B10 Q99714 1/20 0.58
HPGD P15428 1/20 0.52
THRB P10828 2/20 0.43
MAPK1 P28482 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
FGFR4 P22455 1/20 0.38
MAPT P10636 2/20 0.33
CACNA1B Q00975 1/20 0.33
APBA1 Q02410 1/20 0.33
ATM Q13315 1/20 0.31
RAB9A P51151 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7067654 0.89 TSHR (0.68) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL8668389 0.87 TSHR (0.72) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL8156816 0.85 TSHR (0.76) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL22561254 0.84 TSHR (0.55) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL7756676 0.81 TSHR (0.52) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL93462 0.80 TSHR (0.84) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL30604742 0.80 TSHR (0.84) TSHRALDH1A1TP53HIF1ACYP3A4
Urea SCHEMBL28815528 0.79 TSHR (0.50) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL4198066 0.79 TSHR (0.67) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL12547083 0.79 TSHR (0.60) TSHRALDH1A1TP53HIF1ACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220389021-A1 INHIBITORS OF KRAS G12C BEONE MEDICINES I GMBH (CH) 2022-12-08 US disclosed
CN-108017971-A Finish compositions and pattern formation method 罗门哈斯电子材料有限责任公司 2018-05-11 CN disclosed
CN-103339757-B The manufacture method of secondary cell perforated membrane slurry, secondary cell perforated membrane, electrode for secondary battery, secondary battery separator, secondary cell and secondary cell perforated membrane ZEON CORP. (JP) 2015-11-25 CN disclosed
CN-105052644-A Selenium-enriched rice planting method GUANGXI XIEJI AGRICULTURE DEV CO LTD 2015-11-18 CN disclosed
CN-104012630-B A kind of rich selenium water shield bone crisp-fried and preparation method Lichuan City Duo Renduo Industrial Co., Ltd. (CN) 2015-11-18 CN disclosed
CN-104285643-B The production method of rich selenium bamboo shoots DENG TIANHUA (CN) 2015-11-04 CN disclosed
CN-104905274-A Embedding and diluting method for L-selenium methyl selenocysteine UNIV NANCHANG 2015-09-16 CN disclosed
CN-104861137-A Foamed polyurethane with improved flex resistance BASF SE 2015-08-26 CN disclosed
CN-104305444-A Production method for natural bamboo juice rich in selenium DENG TIANHUA 2015-01-28 CN disclosed
CN-104285643-A Production method of selenium-enriched bamboo shoots DENG TIANHUA 2015-01-21 CN disclosed
US-5017433-A Polyurethane, photocurable DELTAGLASS S. A. (CH) 1991-05-21 US disclosed
EP-0347516-A2 Polymerisable hot melt without a solvent and free from or poor in monomers Bolte, Georg, Dr. (DE) 1989-12-27 EP disclosed
EP-0108631-B1 RADIATION-CURABLE ADHESIVE COMPOSITIONS DELTAGLASS S.A. (CH) 1988-03-02 EP disclosed
EP-0108631-A2 Radiation-curable adhesive compositions DELTAGLASS S.A. (CH) 1984-05-16 EP disclosed
EP-0033404-A1 Aldehyde-substituted amide polymers, their preparation and use ROHM AND HAAS COMPANY (US) 1981-08-12 EP disclosed
US-4279959-A Water-insoluble copolymers containing amide-polyaldehyde thermosettable system ROHM AND HAAS COMPANY (US) 1981-07-21 US disclosed
US-4203898-A ANTICARCINOGENIC ELI LILLY AND COMPANY (US) 1980-05-20 US disclosed
US-4199643-A Water-insoluble copolymers containing amide-polyaldehyde thermosettable system ROHM AND HAAS COMPANY (US) 1980-04-22 US disclosed
US-3992333-A NITROGEN AND SULFUR CONTAINING COPOLYMER IS SELF-CROSSLINKING BINDER ROHM AND HAAS COMPANY (US) 1976-11-16 US disclosed
US-3940360-A ACRYLIC POLYMER UNION CARBIDE CORPORATION (US) 1976-02-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220389021-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS TSHR 3765/4885ALDH1A1 3777/4885TP53 4/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.