SCHEMBL7069326

SCHEMBL7069326

O=C(O)/C(F)=C/c1ccc(C(F)(F)F)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.52
AKR1C3 P42330 1/20 0.50
HDAC3 O15379 1/20 0.47
ADAM17 P78536 1/20 0.47
HDAC1 Q13547 1/20 0.47
HDAC2 Q92769 1/20 0.47
HDAC10 Q969S8 1/20 0.47
HDAC11 Q96DB2 1/20 0.47
HDAC8 Q9BY41 1/20 0.47
HDAC6 Q9UBN7 1/20 0.47
HDAC5 Q9UQL6 1/20 0.47
CES2 O00748 1/20 0.45
CES1 P23141 1/20 0.45
PTGS1 P23219 3/20 0.45
PTGS2 P35354 2/20 0.45
NQO2 P16083 1/20 0.45
SRD5A2 P31213 1/20 0.44
CYP1A1 P04798 4/20 0.44
CYP1B1 Q16678 4/20 0.44
MAOB P27338 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7071411 1.00 CYP1A2 (0.52) CYP1A2AKR1C3HDAC3ADAM17HDAC1
SCHEMBL8392279 1.00 CYP1A2 (0.52) CYP1A2AKR1C3HDAC3ADAM17HDAC1
SCHEMBL2957449 0.83 CYP1A2 (0.50) CYP1A2AKR1C3HDAC1SRD5A2
SCHEMBL2957447 0.83 CYP1A2 (0.50) CYP1A2AKR1C3HDAC1SRD5A2
SCHEMBL14280866 0.82 CYP1A2 (0.53) CYP1A2AKR1C3HDAC3ADAM17HDAC1
SCHEMBL30587844 0.82 CYP1A2 (0.53) CYP1A2AKR1C3HDAC3ADAM17HDAC1
SCHEMBL5382427 0.82 TP53 (0.55) CYP1A2AKR1C3HDAC3ADAM17HDAC1
SCHEMBL6933104 0.79 AKR1C3 (0.60) CYP1A2AKR1C3HDAC3ADAM17HDAC1
SCHEMBL6933101 0.79 AKR1C3 (0.60) CYP1A2AKR1C3HDAC3ADAM17HDAC1
SCHEMBL700921 0.79 MAOB (0.50) CES2SRD5A2MAOBP4HB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0946492-B1 NOVEL 2-FLUOROACRYLIC ACID DERIVATIVES, NOVEL MIXTURES OF HERBICIDES AND ANTIDOTES AND THE USE THEREOF BAYER CROPSCIENCE GMBH (DE) 2003-06-18 EP claimed
CN-111592519-B Fluorine-containing carboxylic acid compound and preparation method thereof 四川大学 2021-03-23 CN disclosed
CN-111592519-A Fluorine-containing carboxylic acid compound and preparation method thereof 四川大学 2020-08-28 CN disclosed
EP-0946492-B1 NOVEL 2-FLUOROACRYLIC ACID DERIVATIVES, NOVEL MIXTURES OF HERBICIDES AND ANTIDOTES AND THE USE THEREOF BAYER CROPSCIENCE GMBH (DE) 2003-06-18 EP disclosed
US-5972839-A MIXTURE WITH PLANT SAFENING AGENT HOECHST SCHERING AGREVO GMBH (DE) 1999-10-26 US disclosed
EP-0946492-A1 NOVEL 2-FLUOROACRYLIC ACID DERIVATIVES, NOVEL MIXTURES OF HERBICIDES AND ANTIDOTES AND THE USE THEREOF Hoechst Schering AgrEvo GmbH (DE) 1999-10-06 EP disclosed
WO-1998027049-A1 NOVEL 2-FLUOROACRYLIC ACID DERIVATIVES, NOVEL MIXTURES OF HERBICIDES AND ANTIDOTES AND THE USE THEREOF HOECHST SCHERING AGREVO GMBH (DE) 1998-06-25 WO disclosed