Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.35 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 13/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.33 |
| ▸ | PRKACA | P17612 | 6/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.33 |
| ▸ | PKN2 | Q16513 | 5/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.33 |
| ▸ | STK17A | Q9UEE5 | 5/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6833433 | 0.72 | AKT1 (0.60) | CYP19A1CYP11B2SIRT2SIRT1SIRT3 | |
| Hydrochloric Acid SCHEMBL6931715 | 0.66 | AKT1 (0.67) | CYP19A1CYP11B2MAPK1AKT1CLK4 | |
| SCHEMBL13141937 | 0.61 | CYP19A1 (0.72) | CYP19A1CYP11B2KDM4EMAPTKMT2A | |
| SCHEMBL6931724 | 0.60 | CYP11B2 (0.44) | CYP19A1CYP11B2AKT1CLK4PRKACA | |
| SCHEMBL16946606 | 0.57 | CYP19A1 (1.00) | CYP19A1CYP11B2LMNAMAPTKMT2A | |
| SCHEMBL19046336 | 0.57 | — | — | |
| SCHEMBL7691608 | 0.57 | AKT1 (0.59) | KDM4EAKT1CLK4PRKACAROCK2 | |
| SCHEMBL7691611 | 0.57 | AKT1 (0.59) | KDM4EAKT1CLK4PRKACAROCK2 | |
| SCHEMBL23332034 | 0.56 | CYP19A1 (0.73) | CYP19A1CYP11B2MAPK1MAPTKMT2A | |
| SCHEMBL23332031 | 0.56 | CYP19A1 (0.79) | CYP19A1CYP11B2MAPK1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463505-A2 | 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | Abbott Laboratories (US) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003051366-A2 | 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | ABBOTT LABORATORIES (US) | 2003-06-26 | — | — | WO | disclosed |