⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7624480 | 1.00 | — | — | |
| SCHEMBL7619020 | 1.00 | — | — | |
| SCHEMBL7624474 | 1.00 | — | — | |
| SCHEMBL7069780 | 0.79 | CDK1 (0.33) | — | |
| SCHEMBL7069783 | 0.79 | CDK1 (0.33) | — | |
| SCHEMBL7069782 | 0.79 | CDK1 (0.33) | — | |
| SCHEMBL7784089 | 0.78 | — | — | |
| SCHEMBL7786451 | 0.78 | — | — | |
| SCHEMBL8524329 | 0.72 | HRH4 (0.41) | — | |
| SCHEMBL7786335 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6166060-A | 1H-4(5)-substituted imidazole derivatives | GLIATECH, INC. (US) | 2000-12-26 | — | — | US | claimed |
| EP-1320364-A1 | THE USE OF HISTAMINE H3-RECEPTOR INVERSE AGONISTS FOR THE CONTROL OF APPETITE AND TREATMENT OF OBESITY | GLIATECH, INC. (US) | 2003-06-25 | — | — | EP | disclosed |
| US-20030069295-A1 | Use of histamine H3 receptor inverse agonists for the control of appetite and treatment of obesity | GLIATECH, INC. | 2003-04-10 | — | — | US | disclosed |
| WO-2002015905-A1 | THE USE OF HISTAMINE H3 RECEPTOR INVERSE AGONISTS FOR THE CONTROL OF APPETITE AND TREATMENT OF OBESITY | GLIATECH, INC. (US) | 2002-02-28 | — | — | WO | disclosed |