Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 8/20 | 0.56 |
| ▸ | EDNRB | P24530 | 6/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PTPRC | P08575 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7829178 | 0.89 | EDNRA (0.44) | EDNRAEDNRBPTGS2ALDH1A1 | |
| SCHEMBL6541815 | 0.89 | EDNRA (0.68) | EDNRAEDNRBPTGS2ALDH1A1L3MBTL1 | |
| SCHEMBL7336545 | 0.88 | EDNRA (0.51) | EDNRAEDNRBHCRTR2 | |
| SCHEMBL6541139 | 0.88 | EDNRA (0.59) | EDNRAEDNRBPTGS2ALDH1A1L3MBTL1 | |
| SCHEMBL6541726 | 0.87 | EDNRA (0.58) | EDNRAEDNRBPTGS2ALDH1A1L3MBTL1 | |
| SCHEMBL6541828 | 0.87 | EDNRA (0.60) | EDNRAEDNRBPTGS2ALDH1A1L3MBTL1 | |
| SCHEMBL6541192 | 0.87 | EDNRA (0.60) | EDNRAEDNRBPTGS2ALDH1A1L3MBTL1 | |
| SCHEMBL6542071 | 0.87 | EDNRA (0.58) | EDNRAEDNRBPTGS2ALDH1A1L3MBTL1 | |
| SCHEMBL6541430 | 0.86 | EDNRA (0.58) | EDNRAEDNRBPTGS2ALDH1A1L3MBTL1 | |
| SCHEMBL6542147 | 0.86 | EDNRA (0.57) | EDNRAEDNRBPTGS2ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030232787-A1 | Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic | DOOLEY DAVID JAMES (US) | 2003-12-18 | — | — | US | claimed |
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | claimed |
| WO-1996026195-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1996-08-29 | — | — | WO | claimed |
| US-4087534-A | N-haloalkylmio urazole pesticides | OVADIA DAVID | 1978-05-02 | — | — | US | claimed |
| US-20030232787-A1 | Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic | DOOLEY DAVID JAMES (US) | 2003-12-18 | — | — | US | disclosed |
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | disclosed |
| EP-0811001-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1997-12-10 | — | — | EP | disclosed |
| EP-0500209-B1 | Pesticidal 1-(2-pyridyl)pyrazoles | RHONE POULENC AGROCHIMIE (FR) | 1997-09-17 | — | — | EP | disclosed |
| WO-1996026195-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1996-08-29 | — | — | WO | disclosed |
| US-5306694-A | Miticides, nematocides, aphicides, insecticides; applying to plants | RHONE-POULENC INC. (US) | 1994-04-26 | — | — | US | disclosed |
| EP-0500209-A1 | Pesticidal 1-(2-pyridyl)pyrazoles | RHONE-POULENC AGROCHIMIE (FR) | 1992-08-26 | — | — | EP | disclosed |
| US-4854965-A | SUBSTITUTED 2,4-DIOXO-AND 2,4-DITHIO-1,3-DIHYDROQUINAZOLINES; CONTROLLING BROAD-LEAFED WEEDS IN CEREAL CROPS | MAKHTESHIM CHEMICAL WORKS, LTD. (IL) | 1989-08-08 | — | — | US | disclosed |
| EP-0254049-A2 | Herbicidal compositions | MAKHTESHIM CHEMICAL WORKS LIMITED (IL) | 1988-01-27 | — | — | EP | disclosed |
| US-4551458-A | 1-HALOALKYLTHIO DERIVATIVES | MAKHTESHIM CHEMICAL WORKS, LTD. (IL) | 1985-11-05 | — | — | US | disclosed |
| US-4087534-A | N-haloalkylmio urazole pesticides | OVADIA DAVID | 1978-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030232787-A1 | Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic | EDNRA, EDNRB, ECE1 | EDNRA 1/4885EDNRB 2/4885PTGS2 433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.