Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 9/20 | 0.44 |
| ▸ | EDNRB | P24530 | 6/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CMA1 | P23946 | 1/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7069874 | 0.89 | EDNRA (0.56) | EDNRAEDNRBPTGS2ALDH1A1 | |
| SCHEMBL7071144 | 0.89 | EDNRA (0.50) | EDNRAEDNRB | |
| SCHEMBL7334893 | 0.86 | EDNRA (0.51) | EDNRAEDNRBALDH1A1KDM4EHPGD | |
| SCHEMBL7345193 | 0.86 | EDNRA (0.51) | EDNRAEDNRBALDH1A1KDM4EHPGD | |
| SCHEMBL7830902 | 0.82 | ALDH1A1 (0.36) | EDNRAEDNRBALDH1A1MAPK1CMA1 | |
| SCHEMBL7065610 | 0.80 | EDNRB (0.47) | EDNRAEDNRBALDH1A1CMA1KDM4E | |
| SCHEMBL6541815 | 0.78 | EDNRA (0.68) | EDNRAEDNRBPTGS2ALDH1A1KDM4E | |
| SCHEMBL7336545 | 0.78 | EDNRA (0.51) | EDNRAEDNRBCTNNB1 | |
| SCHEMBL6541139 | 0.77 | EDNRA (0.59) | EDNRAEDNRBPTGS2ALDH1A1CTNNB1 | |
| SCHEMBL6541726 | 0.76 | EDNRA (0.58) | EDNRAEDNRBPTGS2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | claimed |