Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.49 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.49 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | FABP3 | P05413 | 1/20 | 0.46 |
| ▸ | FABP4 | P15090 | 1/20 | 0.46 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.45 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6474153 | 0.99 | KDM4E (0.61) | KDM4EALDH1A1HDAC1HDAC6PTGDR2 | |
| SCHEMBL7069898 | 0.97 | KDM4E (0.58) | KDM4EALDH1A1HDAC1HDAC6PTGDR2 | |
| SCHEMBL6482626 | 0.88 | PTGDR2 (0.64) | KDM4EHDAC1HDAC6PTGDR2CHRM2 | |
| SCHEMBL6475292 | 0.88 | HDAC1 (0.56) | KDM4EALDH1A1HDAC1HDAC6PTGDR2 | |
| SCHEMBL6475536 | 0.87 | HDAC1 (0.55) | KDM4EALDH1A1HDAC1HDAC6PTGDR2 | |
| SCHEMBL6483052 | 0.85 | HDAC6 (0.56) | KDM4EALDH1A1HDAC1HDAC6PTGDR2 | |
| SCHEMBL6474264 | 0.85 | HDAC1 (0.51) | KDM4EALDH1A1HDAC1HDAC6PTGDR2 | |
| SCHEMBL6475353 | 0.85 | HTR5A (0.53) | KDM4EALDH1A1HDAC1HDAC6PTGDR2 | |
| SCHEMBL6475467 | 0.84 | HDAC1 (0.51) | KDM4EALDH1A1HDAC1HDAC6PTGDR2 | |
| SCHEMBL6482437 | 0.83 | HDAC6 (0.59) | KDM4EALDH1A1HDAC1HDAC6PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1319004-A2 | SUBSTITUTED AZEPINO[4,5-B]INDOLE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002024701-A2 | SUBSTITUTED AZEPINO[4,5B)INDOLE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 2002-03-28 | — | — | WO | disclosed |