Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 8/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.48 |
| ▸ | PDE4A | P27815 | 6/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.48 |
| ▸ | PAK4 | O96013 | 1/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | USP1 | O94782 | 1/20 | 0.45 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7071282 | 0.90 | PDE4A (0.53) | LRRK2ADORA2BADORA2APDE4APDE4B | |
| SCHEMBL7066909 | 0.75 | ADORA2A (0.48) | LRRK2ADORA2BADORA2APDE4APDE4B | |
| SCHEMBL7254877 | 0.73 | MAPT (0.50) | CLK4 | |
| SCHEMBL7071101 | 0.73 | ADORA2A (0.53) | LRRK2ADORA2BADORA2APDE4APDE4B | |
| SCHEMBL30092880 | 0.73 | PDE4A (0.52) | LRRK2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21567306 | 0.73 | PDE4A (0.52) | LRRK2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21567304 | 0.73 | PDE4A (0.52) | LRRK2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30092963 | 0.73 | PDE4A (0.52) | LRRK2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21542001 | 0.72 | PDE4A (0.49) | LRRK2ADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL20399148 | 0.72 | PDE4A (0.67) | LRRK2PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003055890-A1 | THIENOPYRIMIDINE DERIVATIVE COMPOUNDS AS INHIBITORS OF PROLYLPEPTIDASE, INDUCERS OF APOPTOSIS AND CANCER TREATMENT AGENTS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-07-10 | — | — | WO | disclosed |