Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.55 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.53 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.48 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.48 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.48 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.43 |
| ▸ | KDM1A | O60341 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10350584 | 0.98 | GBA1 (0.53) | GBA1SOS1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL8326386 | 0.87 | GBA1 (0.50) | GBA1SOS1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL6267837 | 0.85 | HTR2A (0.44) | SOS1SIGMAR1HRH1 | |
| SCHEMBL7437609 | 0.83 | GBA1 (0.42) | GBA1SOS1SIGMAR1SLC6A4 | |
| SCHEMBL27569453 | 0.83 | GBA1 (0.50) | GBA1SOS1CACNA2D1CACNA1BCACNB1 | |
| Hydrochloric Acid SCHEMBL10350611 | 0.82 | GBA1 (0.41) | GBA1SIGMAR1SLC6A4 | |
| SCHEMBL29706726 | 0.81 | CYP2D6 (0.46) | HRH1 | |
| SCHEMBL29706727 | 0.81 | GAA (0.47) | SOS1HRH1 | |
| SCHEMBL8851760 | 0.81 | SOS1 (0.58) | GBA1SOS1CACNA2D1CACNA1BCACNB1 | |
| Hydrochloric Acid SCHEMBL7438746 | 0.80 | GBA1 (0.40) | GBA1SIGMAR1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011121099-A2 | PROCESS FOR THE PREPARATION OF 1-[4-(1,1-DIMETHYLETHYL)PHENYL]-4-[4-(DIPHENYLMETHOXY)-1-PIPERIDINYL]-1-BUTANONE AND ACID ADDITION SALTS THEREOF | AREVIPHARMA GMBH (DE) | 2011-10-06 | — | — | WO | disclosed |
| US-20030065186-A1 | Novel 4-diphenylethyl piperidine derivatives | LING KAH HIING (US) | 2003-04-03 | — | — | US | disclosed |
| US-5618814-A | Trisubstituted pyrimido [5,4-d] pyrimidines for modulating multi-drug resistance and pharmaceutical compositions containing these compounds | DR. KARL THOMAE GMBH (DE) | 1997-04-08 | — | — | US | disclosed |
| EP-0221376-B1 | N-SUBSTITUTED DIPHENYL PIPERIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1990-06-20 | — | — | EP | disclosed |
| EP-0221376-A2 | N-substituted diphenyl piperidines | F. HOFFMANN-LA ROCHE AG (CH) | 1987-05-13 | — | — | EP | disclosed |
| US-4632925-A | INSULIN LOWERING ACTIVITY | HOFFMANN-LA ROCHE INC. (US) | 1986-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030065186-A1 | Novel 4-diphenylethyl piperidine derivatives | HRH4, HRH2, HRH1 | GBA1 2224/4885SOS1 4878/4885CACNA2D1 2208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.