Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10350611 | 0.98 | GBA1 (0.41) | GBA1SLC6A4SLC6A2SLC6A3SIGMAR1 | |
| Hydrochloric Acid SCHEMBL7438746 | 0.97 | GBA1 (0.40) | GBA1SLC6A4SLC6A2SLC6A3SIGMAR1 | |
| SCHEMBL7070397 | 0.83 | GBA1 (0.55) | GBA1SLC6A4SIGMAR1SOS1 | |
| Hydrochloric Acid SCHEMBL10350584 | 0.81 | GBA1 (0.53) | GBA1SIGMAR1SOS1 | |
| SCHEMBL10362352 | 0.80 | CYP19A1 (0.41) | GBA1SLC6A4SLC6A2SLC6A3SOS1 | |
| SCHEMBL27663579 | 0.79 | SLC6A4 (0.37) | SLC6A4SLC6A2SLC6A3SIGMAR1 | |
| SCHEMBL27663578 | 0.79 | CHRM2 (0.40) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL12064481 | 0.78 | SLC6A2 (0.57) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL31388237 | 0.75 | PDE4A (0.44) | — | |
| SCHEMBL12064482 | 0.75 | SLC6A4 (0.51) | SLC6A4SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5070087-A | Aryl(alkyland alkylene)-N-((phenoxy and phenylthio)alkyl) aminoheterocyclics as cardiovascular, anthihistaminic, antisecretory and antiallergy agents | A. H. ROBINS COMPANY, INCORPORATED (US) | 1991-12-03 | — | — | US | disclosed |
| EP-0221376-B1 | N-SUBSTITUTED DIPHENYL PIPERIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1990-06-20 | — | — | EP | disclosed |
| EP-0221376-A2 | N-substituted diphenyl piperidines | F. HOFFMANN-LA ROCHE AG (CH) | 1987-05-13 | — | — | EP | disclosed |
| US-4632925-A | INSULIN LOWERING ACTIVITY | HOFFMANN-LA ROCHE INC. (US) | 1986-12-30 | — | — | US | disclosed |