Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10029229 | 0.81 | MEN1 (0.74) | MEN1KMT2AALDH1A1SMN1; SMN2GAA | |
| SCHEMBL10029222 | 0.81 | KMT2A (0.60) | MEN1KMT2AALDH1A1SMN1; SMN2GAA | |
| Tecovirimat SCHEMBL20126651 | 0.79 | ALDH1A1 (0.73) | MEN1KMT2AALDH1A1SMN1; SMN2GAA | |
| Tecovirimat SCHEMBL10034023 | 0.79 | ALDH1A1 (0.73) | MEN1KMT2AALDH1A1SMN1; SMN2GAA | |
| Tecovirimat SCHEMBL16177983 | 0.79 | ALDH1A1 (0.73) | MEN1KMT2AALDH1A1SMN1; SMN2GAA | |
| Tecovirimat SCHEMBL14601849 | 0.79 | ALDH1A1 (0.73) | MEN1KMT2AALDH1A1SMN1; SMN2GAA | |
| Tecovirimat SCHEMBL404303 | 0.79 | ALDH1A1 (0.73) | MEN1KMT2AALDH1A1SMN1; SMN2GAA | |
| SCHEMBL18691802 | 0.78 | ALDH1A1 (0.76) | MEN1KMT2AALDH1A1SMN1; SMN2GAA | |
| SCHEMBL405810 | 0.74 | ALDH1A1 (0.76) | MEN1KMT2AALDH1A1SMN1; SMN2GAA | |
| SCHEMBL25239750 | 0.72 | PTGS1 (0.63) | MEN1KMT2AALDH1A1GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638938-B1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PREVENTION OF ORTHOPOXVIRUS INFECTIONS AND ASSOCIATED DISEASES | SIGA TECH INC (US) | 2017-04-12 | — | — | EP | claimed |
| US-8124643-B2 | Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases | SIGA TECHNOLOGIES, INC. (US) | 2012-02-28 | — | — | US | claimed |
| US-8039504-B2 | heating a mixture of anti-tricyclo[3.2.2.0]non-6-ene-endo-8, endo-9-dicarboxylic acid anhydride, 4-(trifluoromethyl)benzhydrazide, and ethanol at reflux, concetrating and recrystallizing; 4-Trifluoromethyl-N- (3,3a,4,4a,5,5a,6,6a,- octahydro-1,3-dioxo-4,6- ethenocycloprop[f]isoindol- 2(1H)-yl)-benzamide | SIGA TECHNOLOGIES, INC. (US) | 2011-10-18 | — | — | US | claimed |