Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.31 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.31 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | IGF1R | P08069 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | FLT4 | P35916 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30013654 | 0.79 | PARP1 (0.44) | TDP1PARP1 | |
| SCHEMBL3337344 | 0.79 | PARP1 (0.44) | TDP1PARP1 | |
| SCHEMBL23956603 | 0.77 | KDM4E (0.50) | TDP1KDM4EALDH1A1KCNA5JAK2 | |
| SCHEMBL29909242 | 0.76 | PARP1 (0.42) | TDP1PARP1NPC1RAB9A | |
| SCHEMBL29777989 | 0.76 | ELANE (0.44) | TDP1KDM4EALDH1A1PARP1 | |
| SCHEMBL7336294 | 0.76 | PDPK1 (0.47) | TDP1KDM4EALDH1A1PARP1KCNA5 | |
| SCHEMBL1995692 | 0.76 | PARP1 (0.42) | TDP1PARP1NPC1RAB9A | |
| SCHEMBL1997280 | 0.76 | ELANE (0.44) | TDP1KDM4EALDH1A1PARP1 | |
| SCHEMBL30012748 | 0.76 | PDPK1 (0.47) | TDP1KDM4EALDH1A1PARP1KCNA5 | |
| SCHEMBL30615144 | 0.76 | RXFP1 (0.38) | TDP1KDM4EKCNA5MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003055890-A1 | THIENOPYRIMIDINE DERIVATIVE COMPOUNDS AS INHIBITORS OF PROLYLPEPTIDASE, INDUCERS OF APOPTOSIS AND CANCER TREATMENT AGENTS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-07-10 | — | — | WO | disclosed |