Sugi Predict

Sugi Predict / Compounds / SCHEMBL7336294

SCHEMBL7336294

SCHEMBL7336294

Clc1nc(Cl)c2c(Br)cccc2n1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PDPK1 O15530 1/20 0.47
▸ ELANE P08246 1/20 0.39
▸ TDP1 Q9NUW8 1/20 0.38
▸ BACE1 P56817 1/20 0.36
▸ HTT P42858 1/20 0.33
▸ ENPP3 O14638 1/20 0.33
▸ ENPP1 P22413 1/20 0.33
▸ CYP1A2 P05177 1/20 0.33
▸ PARP1 P09874 1/20 0.32
▸ KDM4E B2RXH2 1/20 0.32
▸ ALDH1A1 P00352 1/20 0.32
▸ KCNA5 P22460 2/20 0.31
▸ JAK2 O60674 1/20 0.31
▸ IGF1R P08069 1/20 0.31
▸ PIM1 P11309 1/20 0.31
▸ SRC P12931 1/20 0.31
▸ CSNK2A2 P19784 1/20 0.31
▸ JAK1 P23458 1/20 0.31
▸ CCNE1 P24864 1/20 0.31
▸ CDK2 P24941 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30012748 1.00 PDPK1 (0.47) PDPK1ELANETDP1BACE1HTT
SCHEMBL28085242 0.84 PDPK1 (0.47) PDPK1ELANETDP1BACE1ENPP3
SCHEMBL21497071 0.81 HTT (0.46) PDPK1ELANEBACE1HTTKDM4E
SCHEMBL29378492 0.81 HTT (0.46) PDPK1ELANEBACE1HTTKDM4E
SCHEMBL30013654 0.79 PARP1 (0.44) ELANETDP1PARP1
SCHEMBL3337344 0.79 PARP1 (0.44) ELANETDP1PARP1
SCHEMBL28165505 0.77 PDPK1 (0.41) PDPK1ELANETDP1CYP1A2KCNA5
SCHEMBL1995692 0.76 PARP1 (0.42) ELANETDP1CYP1A2PARP1
SCHEMBL29909242 0.76 PARP1 (0.42) ELANETDP1CYP1A2PARP1
SCHEMBL29777989 0.76 ELANE (0.44) ELANETDP1PARP1KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250361236-A9 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS GILEAD SCIENCES INC (US) 2025-11-27 — — US disclosed
US-20240400568-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS GILEAD SCIENCES, INC. 2024-12-05 — — US disclosed
EP-4445902-A2 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS Carna Biosciences, Inc. (JP) 2024-10-16 — — EP disclosed
EP-4081305-B1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS CARNA BIOSCIENCES INC (JP) 2024-09-18 — — EP disclosed
US-12054490-B2 Diacylglycerol kinase modulating compounds GILEAD SCIENCES, INC. (US) 2024-08-06 — — US disclosed
CN-118324767-A Diacylglycerol kinase modulating compounds 卡尔那生物科学株式会社 2024-07-12 — — CN disclosed
US-20240182476-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS GILEAD SCIENCES, INC. 2024-06-06 — — US disclosed
CN-117736207-A Diacylglycerol kinase modulating compounds 卡尔那生物科学株式会社 2024-03-22 — — CN disclosed
CN-115362003-B Diacylglycerol kinase modulating compounds 卡尔那生物科学株式会社 2024-03-22 — — CN disclosed
US-11845723-B2 Diacylglycerol kinase modulating compounds GILEAD SCIENCES, INC. (US) 2023-12-19 — — US disclosed
US-20220324866-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS GILEAD SCIENCES, INC. 2022-10-13 — — US disclosed
US-20220324866-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS GILEAD SCIENCES, INC. 2022-10-13 — — US disclosed
WO-2021130638-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS CARNA BIOSCIENCES, INC. (JP) 2021-07-01 — — WO disclosed
WO-2021130638-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS CARNA BIOSCIENCES, INC. (JP) 2021-07-01 — — WO disclosed
CN-110291073-A Heparanase inhibitors and application thereof 贝塔医疗私人有限公司 2019-09-27 — — CN disclosed
CN-107613769-A CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS 润新生物公司 2018-01-19 — — CN disclosed
CN-107278201-A Quinazoline derivatives for the treatment of HIV 吉利德科学公司 2017-10-20 — — CN disclosed
EP-0491814-B1 TETRACYCLIC IMIDAZOQUINAZOLINE DERIVATIVES, PREPARATION AND PHARMACEUTICAL COMPOSITIONS NOVO NORDISK AS (DK) 1995-12-06 — — EP disclosed
US-5100895-A Imidazoquinazoline compounds; anticonvulsants, anxiolytics, hypnotics, antipsychotics, antiemetics, improving cognitive function NOVO NORDISK A/S (DK) 1992-03-31 — — US disclosed
EP-0417027-A1 Tetracyclic imidazoquinazoline derivatives, process for their preparation and pharmaceutical compositions containing them NOVO NORDISK A/S (DK) 1991-03-13 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240400568-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS DGKG, DGKB, DGKK PDPK1 8/4885ELANE 4267/4885TDP1 2436/4885
US-20220324866-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS DGKG, DGKB, DGKK PDPK1 8/4885ELANE 4267/4885TDP1 2436/4885
US-12054490-B2 Diacylglycerol kinase modulating compounds DGKG, DGKB, DGKK PDPK1 8/4885ELANE 4267/4885TDP1 2436/4885
US-11845723-B2 Diacylglycerol kinase modulating compounds DGKG, DGKB, DGKK PDPK1 8/4885ELANE 4267/4885TDP1 2436/4885
US-20240182476-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS DGKG, DGKB, DGKK PDPK1 8/4885ELANE 4267/4885TDP1 2436/4885
US-20250361236-A9 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS DGKG, DGKB, DGKK PDPK1 8/4885ELANE 4267/4885TDP1 2436/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.