SCHEMBL7071680

SCHEMBL7071680

N#Cc1cc(C#N)cc(Oc2cccc(Oc3cc(Cl)nc(Cl)n3)c2)c1

nearest known ligand 0.40

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 3/20 0.40
MAP4K4 O95819 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.39
CKS1B P61024 1/20 0.37
SKP2 Q13309 1/20 0.37
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
CYP19A1 P11511 1/20 0.36
EPAS1 Q99814 1/20 0.36
FFAR1 O14842 1/20 0.35
FFAR4 Q5NUL3 1/20 0.35
SYK P43405 1/20 0.35
JAK2 O60674 1/20 0.35
JAK1 P23458 1/20 0.35
JAK3 P52333 1/20 0.35
F2 P00734 2/20 0.35
F10 P00742 2/20 0.35
PGR P06401 1/20 0.34
AR P10275 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7072032 0.86 MEN1 (0.54) GRM5MAP4K4L3MBTL1CKS1BSKP2
SCHEMBL7071599 0.83 MAP4K4 (0.45) GRM5MAP4K4L3MBTL1CKS1BSKP2
SCHEMBL7071630 0.83 MAPK1 (0.48) GRM5MAP4K4L3MBTL1MEN1KMT2A
SCHEMBL18049170 0.80 GRM5 (0.51) GRM5MAP4K4L3MBTL1MEN1KMT2A
SCHEMBL7077083 0.80 NTRK1 (0.45) GRM5MAP4K4L3MBTL1CYP19A1JAK2
SCHEMBL7076280 0.79 MAP4K4 (0.41) GRM5MAP4K4L3MBTL1MEN1KMT2A
SCHEMBL7070749 0.78 SMN1; SMN2 (0.50) MAP4K4MEN1KMT2ACYP19A1EPAS1
SCHEMBL17608978 0.78 SLC6A2 (0.48) GRM5MAP4K4L3MBTL1MEN1KMT2A
SCHEMBL7074601 0.76 AR (0.54) GRM5MEN1KMT2ACYP19A1EPAS1
SCHEMBL7074948 0.76 AR (0.54) GRM5MEN1KMT2ACYP19A1EPAS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030181334-A1 Herbicidal method BAYER CROPSCIENCE LIMITED (GB) 2003-09-25 US disclosed
WO-2003051119-A1 NEW HERBICIDAL COMPOUNDS AND METHOD BAYER CROPSCIENCE LIMITED (GB) 2003-06-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030181334-A1 Herbicidal method DDT, HAAO, CYP4X1 GRM5 792/4885MAP4K4 4418/4885L3MBTL1 2135/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.