Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | NT5E | P21589 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27319191 | 0.79 | NR3C2 (0.44) | PDE10AMAPK9MAPK10MAPK8MDM2 | |
| SCHEMBL27344729 | 0.78 | NOTUM (0.51) | PDE10AMAPK9MAPK10MAPK8MDM2 | |
| SCHEMBL1155787 | 0.76 | MDM2 (0.55) | PDE10AMAPK9MAPK10MAPK8MDM2 | |
| SCHEMBL27344726 | 0.75 | PDE10A (0.48) | PDE10AMAPK9MAPK10MAPK8MDM2 | |
| SCHEMBL27325282 | 0.75 | AKT1 (0.50) | PDE10AMAPK9MAPK10MAPK8MDM2 | |
| SCHEMBL10040322 | 0.74 | PDE10A (0.71) | PDE10AMAPK9MAPK10MAPK8MDM2 | |
| SCHEMBL5907310 | 0.73 | MAPK9 (0.56) | MAPK9MAPK10MAPK8MDM2NR3C2 | |
| SCHEMBL7370402 | 0.73 | CYP1A2 (0.51) | PDE10AMDM2NR3C2ALDH1A1LMNA | |
| SCHEMBL17086633 | 0.72 | MDM2 (0.52) | MAPK9MAPK10MAPK8MDM2NR3C2 | |
| SCHEMBL27310701 | 0.72 | MEN1 (0.51) | MAPK9MAPK10MAPK8MDM2NR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003045950-A1 | PYRAZOLOPYRIDINE DERIVTIVES AND THEIR PHARMACEUTICAL USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-05 | — | — | WO | disclosed |
| WO-2002100864-A1 | PYRAZOLOPYRAZINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-12-19 | — | — | WO | disclosed |
| CN-1031570-C | Pyrazolopyridine compound and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-04-17 | — | — | CN | disclosed |
| CN-1044656-A | Pyrazolopyridine compound and preparation method thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1990-08-15 | — | — | CN | disclosed |