Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21054355 | 0.84 | HSP90AB1 (0.42) | TSHRKAT2BHPGDKMT2AALDH1A1 | |
| SCHEMBL17533163 | 0.83 | CYP4F2 (0.50) | KAT2BALDH1A1MAPTCYP1A2GAA | |
| SCHEMBL14645460 | 0.80 | RPS6KB2 (0.43) | TSHRRPS6KB2KAT2BHPGDKMT2A | |
| SCHEMBL15774072 | 0.78 | NPSR1 (0.48) | HPGDLMNAMAPTL3MBTL1 | |
| SCHEMBL18050370 | 0.77 | IAPP (0.44) | ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL29147854 | 0.77 | GSK3B (0.35) | MAPTL3MBTL1 | |
| SCHEMBL1569441 | 0.75 | TNKS2 (0.36) | TSHRALDH1A1HTTGAA | |
| SCHEMBL5007610 | 0.74 | CYP4F2 (0.48) | KAT2BCYP1A2 | |
| SCHEMBL14645332 | 0.74 | HSP90AB1 (0.42) | TSHRKAT2BHPGDKMT2AALDH1A1 | |
| SCHEMBL31176880 | 0.73 | RPS6KB2 (0.38) | TSHRRPS6KB2KAT2BHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318979-A1 | CYCLOPENTANE DERIVATIVES AS THERAPEUTIC AGENTS | Allergan Sales, Inc. (US) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002024639-A1 | CYCLOPENTANE DERIVATIVES AS THERAPEUTIC AGENTS | ALLERGAN, INC. (US) | 2002-03-28 | — | — | WO | disclosed |
| US-6359181-B1 | THERAPY FOR VISION DEFECTS | ALLERGAN SALES, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6307092-B1 | POTENT OCULAR HYPOTENSIVES AND ARE PARTICULARLY SUITED FOR THE MANAGEMENT OF GLAUCOMA. | ALLERGAN SALES, INC. | 2001-10-23 | — | — | US | disclosed |
| US-6248783-B1 | GLAUCOMA THERAPY | ALLERGAN SALES, INC. | 2001-06-19 | — | — | US | disclosed |