Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 14/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | F9 | P00740 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7075919 | 0.94 | F10 (0.51) | F10KCNH2 | |
| SCHEMBL7079641 | 0.89 | F10 (0.47) | F10KCNH2F2F9PRSS1 | |
| SCHEMBL7082964 | 0.86 | F10 (0.40) | F10KCNH2F2F9PRSS1 | |
| SCHEMBL7073958 | 0.86 | F10 (0.49) | F10KCNH2 | |
| SCHEMBL6949865 | 0.86 | F10 (0.47) | F10KCNH2 | |
| SCHEMBL7076896 | 0.85 | F10 (0.49) | F10KCNH2 | |
| SCHEMBL7080109 | 0.84 | F10 (0.53) | F10KCNH2 | |
| SCHEMBL6953621 | 0.83 | F10 (0.48) | F10KCNH2 | |
| SCHEMBL5239546 | 0.83 | F10 (0.51) | F10 | |
| SCHEMBL5204047 | 0.82 | F10 (0.56) | F10F2F9PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307444-A2 | SUBSTITUTED HETEROCYCLIC AMIDES | ELI LILLY AND COMPANY (US) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002010154-A2 | SUBSTITUTED HETEROCYCLIC AMIDES | ELI LILLY AND COMPANY (US) | 2002-02-07 | — | — | WO | disclosed |