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SCHEMBL7082964

SCHEMBL7082964

Cc1ccc(NC(=O)c2cc(C)ccc2NC(=O)c2cnc(N3CCCC(C(=O)OC(C)(C)C)NC3)cn2)nc1

nearest known ligand 0.40

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ F10 P00742 14/20 0.40
▸ KCNH2 Q12809 4/20 0.38
▸ TP53 P04637 2/20 0.37
▸ MAPT P10636 1/20 0.37
▸ F2 P00734 1/20 0.36
▸ F9 P00740 1/20 0.36
▸ PRSS1 P07477 1/20 0.36
▸ PRSS2 P07478 1/20 0.36
▸ F7 P08709 1/20 0.36
▸ PRSS3 P35030 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7073397 0.86 F10 (0.43) F10KCNH2MAPTF2F9
SCHEMBL7080767 0.86 F10 (0.50) F10KCNH2
SCHEMBL6953621 0.83 F10 (0.48) F10KCNH2
SCHEMBL5207668 0.81 MAPT (0.48) F10KCNH2TP53MAPT
SCHEMBL7075919 0.81 F10 (0.51) F10KCNH2
SCHEMBL6950657 0.81 F10 (0.45) F10KCNH2
SCHEMBL6949865 0.81 F10 (0.47) F10KCNH2
SCHEMBL5239546 0.78 F10 (0.51) F10
SCHEMBL5204047 0.77 F10 (0.56) F10F2F9PRSS1PRSS2
SCHEMBL5201480 0.77 F10 (0.49) F10KCNH2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1307444-A2 SUBSTITUTED HETEROCYCLIC AMIDES ELI LILLY AND COMPANY (US) 2003-05-07 — — EP disclosed
WO-2002010154-A2 SUBSTITUTED HETEROCYCLIC AMIDES ELI LILLY AND COMPANY (US) 2002-02-07 — — WO disclosed