SCHEMBL7073765

SCHEMBL7073765

CO/N=C(/C(=O)O)c1csc(NC(=O)CCl)n1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.62
GAA P10253 2/20 0.62
MAPT P10636 1/20 0.62
CYP1A2 P05177 1/20 0.45
CYP2C19 P33261 1/20 0.45
KDM4E B2RXH2 2/20 0.43
ALDH1A1 P00352 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
CDK5 Q00535 3/20 0.40
CDK5R1 Q15078 3/20 0.40
RAB9A P51151 3/20 0.39
SMN1; SMN2 Q16637 3/20 0.39
NPC1 O15118 2/20 0.39
CASP2 P42575 1/20 0.39
USP2 O75604 1/20 0.39
ALOX15 P16050 1/20 0.39
HSD17B10 Q99714 1/20 0.39
CASP3 P42574 1/20 0.39
SENP7 Q9BQF6 1/20 0.39
CGAS Q8N884 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5442221 1.00 LMNA (0.62) LMNAGAAMAPTCYP1A2CYP2C19
SCHEMBL5441700 1.00 LMNA (0.62) LMNAGAAMAPTCYP1A2CYP2C19
Hydrochloric Acid SCHEMBL11317116 0.99 LMNA (0.61) LMNAGAAMAPTCYP1A2CYP2C19
Hydrochloric Acid SCHEMBL10332648 0.99 LMNA (0.61) LMNAGAAMAPTCYP1A2CYP2C19
SCHEMBL11495499 0.90 LMNA (0.53) LMNAGAAMAPTCYP1A2CYP2C19
SCHEMBL5438546 0.90 LMNA (0.53) LMNAGAAMAPTCYP1A2CYP2C19
SCHEMBL8314674 0.90 LMNA (0.50) LMNAGAAMAPTCYP1A2CYP2C19
SCHEMBL5438548 0.90 LMNA (0.53) LMNAGAAMAPTCYP1A2CYP2C19
SCHEMBL10777148 0.90 LMNA (0.50) LMNAGAAMAPTCYP1A2CYP2C19
Hydrochloric Acid SCHEMBL9074932 0.89 LMNA (0.52) LMNAGAAMAPTCYP1A2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4203899-A Thiazolylacetamido compounds TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1980-05-20 US claimed
EP-0859002-B1 Process for producing chloroacetylaminothiazoleacetic acid derivatives TOKUYAMA CORP (JP) 2003-07-02 EP disclosed
EP-0859002-A1 Process for producing chloroacetylaminothiazoleacetic acid derivatives TOKUYAMA CORPORATION (JP) 1998-08-19 EP disclosed
US-5583216-A Methods for the manufacture of cephems TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-12-10 US disclosed
EP-0191989-B1 ANTIBIOTIC ISOXAZOLE DERIVATIVES, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1992-09-02 EP disclosed
US-4973684-A Cephem compounds TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1990-11-27 US disclosed
EP-0186586-B1 CEPHEM COMPOUNDS AND THE PRODUCTION THEREOF MEIJI SEIKA KAISHA LTD. (JP) 1990-09-26 EP disclosed
US-4912212-A Cephem compounds TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1990-03-27 US disclosed
US-4687769-A ANTIBIOTICS MEIJI SEIKA KAISHA, LTD. (JP) 1987-08-18 US disclosed
US-4680390-A CEPHALOSPORINS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1987-07-14 US disclosed
EP-0186586-A2 Cephem compounds and the production thereof MEIJI SEIKA KAISHA LTD. (JP) 1986-07-02 EP disclosed
US-4520194-A BACTERICIDES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1985-05-28 US disclosed
US-4514565-A Thiazolylacetamido cephalosphorin compounds TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1985-04-30 US disclosed
US-4510138-A 7-[2-(2-Aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]cephalosporin derivatives TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1985-04-09 US disclosed
US-4355160-A Thiazolylacetamido cephalosporin type compounds TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1982-10-19 US disclosed
US-4298606-A Thiazolylacetamido compounds TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1981-11-03 US disclosed
US-4278671-A ANTIBIOTICS, BACTERICIDES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1981-07-14 US disclosed
US-4205180-A CHEMICAL INTERMEDIATES FOR NOVEL CEPHALOSPORIN COMPOUNDS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1980-05-27 US disclosed
US-4203899-A Thiazolylacetamido compounds TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1980-05-20 US disclosed
US-4098888-A THIAZOLYLACETAMIDO CEPHALOSPORIN TYPE COMPOUNDS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1978-07-04 US disclosed