Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 19/20 | 0.63 |
| ▸ | HDAC2 | Q92769 | 13/20 | 0.63 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.63 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.63 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.63 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.63 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.63 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.63 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.63 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.63 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5852363 | 0.94 | HDAC1 (0.71) | HDAC1HDAC2HDAC6HDAC3HDAC10 | |
| SCHEMBL5852592 | 0.94 | HDAC1 (0.71) | HDAC1HDAC2HDAC6HDAC3HDAC10 | |
| SCHEMBL5852570 | 0.83 | HDAC1 (0.72) | HDAC1HDAC2HDAC6HDAC3HDAC10 | |
| SCHEMBL5852509 | 0.80 | HDAC1 (0.66) | HDAC1HDAC2HDAC6HDAC3HDAC10 | |
| SCHEMBL5852574 | 0.78 | HDAC1 (0.66) | HDAC1HDAC2HDAC6HDAC3HDAC10 | |
| SCHEMBL5852357 | 0.78 | HDAC1 (1.00) | HDAC1HDAC2HDAC6HDAC3HDAC10 | |
| SCHEMBL5852664 | 0.78 | HDAC1 (1.00) | HDAC1HDAC2HDAC6HDAC3HDAC10 | |
| SCHEMBL9757223 | 0.74 | KDM4E (0.44) | HDAC1HDAC2HDAC6HDAC3HDAC10 | |
| SCHEMBL27497045 | 0.72 | NPC1 (0.43) | HDAC1HDAC2HDAC6HDAC3HDAC10 | |
| SCHEMBL4890668 | 0.71 | HDAC1 (0.60) | HDAC1HDAC2HDAC6HDAC3HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358168-A1 | TRICYCLIC LACTAM AND SULTAM DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-05 | — | — | EP | claimed |
| WO-2002062773-A1 | TRICYCLIC LACTAM AND SULTAM DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-15 | — | — | WO | claimed |