Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.69 |
| ▸ | MC5R | P33032 | 1/20 | 0.69 |
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KDM1A | O60341 | 2/20 | 0.56 |
| ▸ | FAAH | O00519 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7069355 | 0.93 | NPC1 (0.77) | MC4RMC5RNPC1KMT2AMEN1 | |
| SCHEMBL7069999 | 0.89 | MC4R (0.72) | MC4RMC5RNPC1KMT2AMEN1 | |
| SCHEMBL7069901 | 0.85 | KDM4E (0.72) | NPC1KMT2AMEN1KDM1AKDM4E | |
| SCHEMBL7070601 | 0.85 | TSHR (0.67) | NPC1KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL7074519 | 0.83 | KDM4E (0.61) | KMT2AMEN1KDM4EALDH1A1LMNA | |
| SCHEMBL9613681 | 0.81 | KDM1A (0.68) | MC4RMC5RNPC1KMT2AMEN1 | |
| SCHEMBL7071898 | 0.80 | LSS (0.68) | KMT2AMEN1KDM1AKDM4EALDH1A1 | |
| SCHEMBL7075117 | 0.79 | KDM1A (0.68) | NPC1KMT2AMEN1KDM1AKDM4E | |
| SCHEMBL3238639 | 0.78 | MAPK1 (0.61) | NPC1KMT2AMEN1KDM1AKDM4E | |
| SCHEMBL7986772 | 0.78 | F10 (0.57) | MC4RMC5RNPC1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-6492368-B1 | Benzamidine derivatives as factor XA inhibitors | MERCK PATENT GMBH (DE) | 2002-12-10 | — | — | US | disclosed |