Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.72 |
| ▸ | MC5R | P33032 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | CHKA | P35790 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | PLAU | P00749 | 3/20 | 0.54 |
| ▸ | F2 | P00734 | 1/20 | 0.54 |
| ▸ | PLG | P00747 | 1/20 | 0.54 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.54 |
| ▸ | KLK1 | P06870 | 1/20 | 0.54 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.52 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.51 |
| ▸ | FAAH | O00519 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7074145 | 0.89 | MC4R (0.69) | MC4RMC5RKMT2APKMNPC1 | |
| SCHEMBL7069355 | 0.86 | NPC1 (0.77) | MC4RMC5RKMT2ANPC1MEN1 | |
| SCHEMBL7986772 | 0.86 | F10 (0.57) | MC4RMC5RKMT2APKMNPC1 | |
| SCHEMBL7074115 | 0.83 | KDM4E (0.59) | MC4RMC5RKMT2APKMPLG | |
| SCHEMBL27999347 | 0.83 | KMT2A (0.89) | MC4RMC5RKMT2APKMCHKA | |
| SCHEMBL4750742 | 0.81 | KMT2A (1.00) | MC4RMC5RKMT2APKMCHKA | |
| SCHEMBL7999912 | 0.80 | MC4R (0.54) | MC4RMC5RKMT2APKMNPC1 | |
| SCHEMBL7999994 | 0.80 | MC4R (0.54) | MC4RMC5RKMT2APKMNPC1 | |
| Acetic Acid SCHEMBL27550435 | 0.79 | ALDH1A1 (0.57) | KMT2APKMF2PLGPRSS1 | |
| SCHEMBL20878517 | 0.77 | LMNA (0.62) | MC4RCHKAPRSS1ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-6492368-B1 | Benzamidine derivatives as factor XA inhibitors | MERCK PATENT GMBH (DE) | 2002-12-10 | — | — | US | disclosed |
| EP-1025086-A1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GmbH (DE) | 2000-08-09 | — | — | EP | disclosed |
| WO-1999016751-A1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 1999-04-08 | — | — | WO | disclosed |