Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.50 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GLS | O94925 | 2/20 | 0.42 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 2/20 | 0.40 |
| ▸ | KAT7 | O95251 | 1/20 | 0.40 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1785143 | 0.95 | SCN9A (0.53) | SCN9ANR1H2MEN1ALDH1A1MAPT | |
| SCHEMBL1785144 | 0.95 | SCN9A (0.53) | SCN9ANR1H2MEN1ALDH1A1MAPT | |
| SCHEMBL2955344 | 0.95 | SCN9A (0.53) | SCN9ANR1H2MEN1ALDH1A1MAPT | |
| SCHEMBL624013 | 0.93 | SCN9A (0.54) | SCN9AMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL3713816 | 0.93 | SCN9A (0.52) | SCN9ANR1H2MEN1ALDH1A1MAPT | |
| SCHEMBL31420855 | 0.91 | SCN9A (0.50) | SCN9ANR1H2MEN1ALDH1A1MAPT | |
| SCHEMBL31421097 | 0.91 | SCN9A (0.50) | SCN9ANR1H2MEN1ALDH1A1MAPT | |
| SCHEMBL7448268 | 0.89 | NR1H2 (0.52) | SCN9ANR1H2MEN1ALDH1A1MAPT | |
| SCHEMBL613607 | 0.87 | GPR119 (0.47) | SCN9ANR1H2MEN1ALDH1A1MAPT | |
| SCHEMBL2241775 | 0.87 | GPR119 (0.47) | SCN9ANR1H2MEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421828-A2 | PIPERIDINE DERIVATIVES AS INHIBITORS OF RENIN | Cadila Healthcare Limited (IN) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010122580-A2 | NOVEL COMPOUNDS AS INHIBITORS OF RENIN | CADILA HEALTHCARE LIMITED (IN) | 2010-10-28 | — | — | WO | disclosed |