Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Silver. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL263364 | 0.91 | POLB (0.37) | POLBCYP3A4TSHRPIK3CAALDH1A1 | |
| SCHEMBL392463 | 0.86 | POLB (0.35) | POLBCYP3A4TSHRPIK3CAALDH1A1 | |
| Hydrochloric Acid SCHEMBL2142090 | 0.86 | POLB (0.35) | POLBCYP3A4TSHRPIK3CAALDH1A1 | |
| Hydrochloric Acid SCHEMBL4059263 | 0.86 | POLB (0.35) | POLBCYP3A4TSHRPIK3CAALDH1A1 | |
| SCHEMBL25011939 | 0.82 | POLB (0.33) | POLBCYP3A4TSHRPIK3CAALDH1A1 | |
| SCHEMBL682204 | 0.82 | POLB (0.33) | POLBCYP3A4TSHRPIK3CAALDH1A1 | |
| SCHEMBL6568058 | 0.80 | POLB (0.37) | POLBCYP3A4TSHRPIK3CAALDH1A1 | |
| SCHEMBL7074852 | 0.78 | POLB (0.32) | POLBCYP3A4TSHRPIK3CAALDH1A1 | |
| SCHEMBL9442614 | 0.78 | POLB (0.32) | POLBCYP3A4TSHRPIK3CAALDH1A1 | |
| Hydrochloric Acid SCHEMBL6865152 | 0.76 | POLB (0.35) | POLBCYP3A4TSHRPIK3CAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1324119-A1 | Imaging element containing incorporated photographically useful compounds | EASTMAN KODAK COMPANY (US) | 2003-07-02 | — | — | EP | disclosed |