Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 4/20 | 0.48 |
| ▸ | PLG | P00747 | 2/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.48 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.45 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.42 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7653179 | 0.84 | SMN1; SMN2 (0.53) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL7071711 | 0.76 | F10 (0.48) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL7071622 | 0.76 | SMYD3 (0.50) | EPHX2KMT2ALMNAMEN1BMPR1B | |
| SCHEMBL7071921 | 0.76 | KMT2A (0.68) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL7075127 | 0.75 | F10 (0.47) | F2PRSS1PRSS2PRSS3ST14 | |
| SCHEMBL7071743 | 0.74 | KDM1A (0.47) | KMT2AMEN1ITGB3ITGA2B | |
| SCHEMBL7074195 | 0.73 | HPGD (0.54) | F2PRSS1PRSS2PRSS3KMT2A | |
| SCHEMBL7076738 | 0.72 | KDM4E (0.51) | KMT2ALMNAMEN1 | |
| SCHEMBL24065200 | 0.72 | HPGD (0.70) | KMT2AMEN1ITGB3ITGA2B | |
| Acetic Acid SCHEMBL27550421 | 0.72 | FASN (0.64) | PRSS1PRSS2PRSS3KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| EP-1025086-A1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GmbH (DE) | 2000-08-09 | — | — | EP | disclosed |
| WO-1999016751-A1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 1999-04-08 | — | — | WO | disclosed |