Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.42 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7649427 | 0.87 | SMYD3 (0.54) | SMYD3MAPK14MGLLKMT2AEPHX2 | |
| SCHEMBL7076841 | 0.80 | MGLL (0.54) | MAPK14MGLLHDAC4LMNAHDAC6 | |
| SCHEMBL7071414 | 0.80 | FASN (0.60) | MGLLKMT2AHDAC4MEN1HDAC6 | |
| SCHEMBL7077120 | 0.80 | MGLL (0.47) | SMYD3MGLLHDAC4LMNAHDAC6 | |
| SCHEMBL7074246 | 0.78 | LMNA (0.52) | MGLLKMT2ALMNAMEN1 | |
| SCHEMBL7074106 | 0.77 | HDAC4 (0.58) | MGLLKMT2AHDAC4LMNAMEN1 | |
| SCHEMBL7070524 | 0.77 | STAT3 (0.52) | EPHX2HDAC4LMNAHDAC6HDAC2 | |
| SCHEMBL7070301 | 0.77 | MGLL (0.52) | MGLLHDAC4LMNAHDAC6PLK1 | |
| SCHEMBL7074872 | 0.76 | F2 (0.48) | KMT2AEPHX2LMNAMEN1BMPR1B | |
| SCHEMBL7073874 | 0.76 | MAPT (0.52) | MGLLKMT2AHDAC4LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| EP-1025086-A1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GmbH (DE) | 2000-08-09 | — | — | EP | disclosed |
| WO-1999016751-A1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 1999-04-08 | — | — | WO | disclosed |