SCHEMBL7075864

SCHEMBL7075864

Nc1ncnc2c1ncn2[C@H]1C[C@H](OP(N)O)[C@@H](CO)O1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADA P00813 1/20 0.54
ADORA3 P0DMS8 3/20 0.53
ADORA2A P29274 2/20 0.53
ADORA1 P30542 2/20 0.53
SMN1; SMN2 Q16637 2/20 0.53
PI4KA P42356 2/20 0.53
PI4K2B Q8TCG2 2/20 0.53
PI4K2A Q9BTU6 2/20 0.53
PI4KB Q9UBF8 2/20 0.53
ADORA2B P29275 2/20 0.53
DPP4 P27487 1/20 0.53
MEN1 O00255 1/20 0.53
SLC28A1 O00337 1/20 0.53
MAP3K7 O43318 1/20 0.53
SLC28A2 O43868 1/20 0.53
GAPDH P04406 1/20 0.53
MAPK1 P28482 1/20 0.53
STAT6 P42226 1/20 0.53
KMT2A Q03164 1/20 0.53
DOT1L Q8TEK3 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31206982 1.00 ADA (0.54) ADAADORA3ADORA2AADORA1SMN1; SMN2
SCHEMBL7739553 0.89 POLB (0.49) ADAADORA1SMN1; SMN2PI4KAPI4K2B
SCHEMBL4580716 0.87 ADA (0.58) ADAADORA3ADORA2AADORA1SMN1; SMN2
SCHEMBL4580720 0.87 ADA (0.58) ADAADORA3ADORA2AADORA1SMN1; SMN2
SCHEMBL10446527 0.87 ADA (0.58) ADAADORA3ADORA2AADORA1SMN1; SMN2
SCHEMBL16360128 0.86 ADA (0.57) ADAADORA3ADORA2AADORA1SMN1; SMN2
SCHEMBL15832423 0.86 ADA (0.57) ADAADORA3ADORA2AADORA1SMN1; SMN2
SCHEMBL22300661 0.86 ADA (0.57) ADAADORA3ADORA2AADORA1SMN1; SMN2
SCHEMBL10432419 0.86 ADA (0.57) ADAADORA3ADORA2AADORA1SMN1; SMN2
SCHEMBL26031198 0.86 ADA (0.57) ADAADORA3ADORA2AADORA1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0628051-B1 APPLICATIONS OF FLUORESCENT N-NUCLEOSIDES AND FLUORESCENT STRUCTURAL ANALOGS OF N-NUCLEOSIDES CHROMAGEN INC (US) 2003-07-02 EP disclosed
US-6268132-B1 AMPLIFICATION, SEQUENCING, REPLICATION, TRANSCRIPITION, ENZYMATIC DIGESTION, HYBRIDIZATION, MEDICAL DIAGNOSIS CHROMAGEN, INC. 2001-07-31 US disclosed
US-5763167-A Applications of fluorescent N-nucleosides and fluorescent structural analogs of N-nucleosides CHROMAGEN (US) 1998-06-09 US disclosed
US-5728525-A RNA AND DNA WITH FLUORESCENT GROUPS FORMED BY ENZYME OR CHEMICAL SYNTHESIS CHROMAGEN, INC. (US) 1998-03-17 US disclosed
US-5652099-A FOR USE IN SYNTHESIS OF FLUORESCENT OLIGONUCLEOTIDES CONRAD MICHAEL J (US) 1997-07-29 US disclosed