⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8380775 | 1.00 | — | — | |
| SCHEMBL11851085 | 0.89 | GAA (0.38) | — | |
| SCHEMBL1694487 | 0.76 | — | — | |
| SCHEMBL9419612 | 0.75 | GAA (0.39) | — | |
| SCHEMBL5585816 | 0.75 | GAA (0.31) | — | |
| SCHEMBL1117725 | 0.73 | GAA (0.30) | — | |
| SCHEMBL21078166 | 0.73 | GAA (0.30) | — | |
| SCHEMBL23740134 | 0.72 | TSHR (0.35) | — | |
| SCHEMBL17099624 | 0.71 | — | — | |
| SCHEMBL5585356 | 0.69 | GAA (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1145619-C | 1-4-benzothiazepine-1,1-dioxide derivatives substituted by sugar radicals, methods for the production thereof, medicaments containing these compounds and the use thereof | ���ĵ�˹ҩ��¹�����˾ | 2004-04-14 | — | — | CN | disclosed |
| EP-1169313-B1 | 1,4-BENZOTHIAZEPINE-1,1-DIOXIDE DERIVATIVES SUBSTITUTED BY SUGAR RADICALS, METHODS FOR THE PRODUCTION THEREOF, MEDICAMENTS CONTAINING THESE COMPOUNDS AND THE USE THEREOF | AVENTIS PHARMA GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| EP-0775126-B1 | HYPOLIPIDEMIC 1,4-BENZOTHIAZEPINE-1,1-DIOXIDES | WELLCOME FOUND (GB) | 2002-10-30 | — | — | EP | disclosed |
| EP-0683774-B1 | HYPOLIPIDAEMIC COMPOUNDS | WELLCOME FOUND (GB) | 2002-10-09 | — | — | EP | disclosed |
| EP-1203769-A1 | Hypolipidemic 1,4-benzothiazepine derivative | THE WELLCOME FOUNDATION LIMITED (GB) | 2002-05-08 | — | — | EP | disclosed |
| CN-1346352-A | 1, 4-benzothiazepine-1, 1-dioxide derivatives substituted by sugar radicals, method for the production thereof, medicaments containing these compounds and the use thereof | AVENTIS PHARMA GMBH (DE) | 2002-04-24 | — | — | CN | disclosed |
| EP-1169313-A2 | 1,4-BENZOTHIAZEPINE-1,1-DIOXIDE DERIVATIVES SUBSTITUTED BY SUGAR RADICALS, METHODS FOR THE PRODUCTION THEREOF, MEDICAMENTS CONTAINING THESE COMPOUNDS AND THE USE THEREOF | Aventis Pharma Deutschland GmbH (DE) | 2002-01-09 | — | — | EP | disclosed |
| US-6277831-B1 | TREATMENT OF HYPERLIPIDEMIA, ARTERIOSCLEROSIS HYPERCHOLESTEROLEMIA; HYPOLIPIDEMIC ACTION; HIGHER EXCRETION OF BILE ACID EVEN AT A LOWER DOSAGE | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-08-21 | — | — | US | disclosed |
| CN-1059673-C | Hypolipidemic 1, 4-benzazepine * -1, 1-dioxides | WELLCOME FOUND (GB) | 2000-12-20 | — | — | CN | disclosed |
| WO-2000061568-A2 | 1,4-BENZOTHIAZEPINE-1,1-DIOXIDE DERIVATIVES SUBSTITUTED BY SUGAR RADICALS, METHODS FOR THE PRODUCTION THEREOF, MEDICAMENTS CONTAINING THESE COMPOUNDS AND THE USE THEREOF | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-10-19 | — | — | WO | disclosed |
| US-5817652-A | ATHEROSCLEROSIS | GLAXO WELLCOME INC. (US) | 1998-10-06 | — | — | US | disclosed |
| US-5723458-A | 1,4-BENZOTHIAZEPINES | GLAXO WELLCOME INC. (US) | 1998-03-03 | — | — | US | disclosed |
| CN-1161035-A | Hypolipidemic 1,4-benzothiazepine-1,1-dioxides | WELLCOME FOUND (GB) | 1997-10-01 | — | — | CN | disclosed |
| EP-0683773-B1 | HYPOLIPIDAEMIC CONDENSED 1,4-THIAZEPINES | WELLCOME FOUND (GB) | 1997-09-17 | — | — | EP | disclosed |
| US-5663165-A | ANTICHOLESTEROL, CARDIOVASCULAR | GLAXO WELLCOME INC. (US) | 1997-09-02 | — | — | US | disclosed |
| EP-0683773-A1 | HYPOLIPIDAEMIC CONDENSED 1,4-THIAZEPINES. | WELLCOME FOUND (GB) | 1995-11-29 | — | — | EP | disclosed |
| EP-0626952-A1 | HYPOLIPIDAEMIC BENZOTHIAZEPINE COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-12-07 | — | — | EP | disclosed |
| WO-1994018184-A1 | HYPOLIPIDAEMIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-08-18 | — | — | WO | disclosed |
| WO-1994018183-A1 | HYPOLIPIDAEMIC CONDENSED 1,4-THIAZEPINES | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-08-18 | — | — | WO | disclosed |
| WO-1993016055-A1 | HYPOLIPIDAEMIC BENZOTHIAZEPINE COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-08-19 | — | — | WO | disclosed |