Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 10/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.48 |
| ▸ | DAO | P14920 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.46 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6303578 | 0.84 | CCR2 (0.62) | CCR2ALDH1A1 | |
| SCHEMBL6303082 | 0.84 | CCR2 (0.62) | CCR2GPR35 | |
| SCHEMBL3963484 | 0.82 | F10 (0.64) | CCR2 | |
| SCHEMBL5378162 | 0.80 | CCR2 (1.00) | CCR2ALDH1A1CYP1A2POLBGPR35 | |
| SCHEMBL6307832 | 0.80 | CCR2 (0.65) | CCR2 | |
| SCHEMBL3959057 | 0.80 | F10 (0.64) | CCR2 | |
| SCHEMBL3958973 | 0.80 | F10 (0.68) | — | |
| SCHEMBL3967220 | 0.79 | CCR2 (0.64) | CCR2ALDH1A1CYP1A2POLB | |
| SCHEMBL3963131 | 0.78 | F10 (0.63) | CCR2 | |
| SCHEMBL3961949 | 0.78 | CCR2 (1.00) | CCR2GPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003504-B1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2003-07-02 | — | — | EP | disclosed |