Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.56 |
| ▸ | PARP1 | P09874 | 10/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.53 |
| ▸ | PIM1 | P11309 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | AKT1 | P31749 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.53 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.50 |
| ▸ | IP6K1 | Q92551 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13948933 | 0.92 | MKNK1 (0.60) | MKNK1PARP1CHEK1PIM1ALDH1A1 | |
| SCHEMBL9704471 | 0.80 | MAPT (0.48) | PARP1CHEK1PIM1ALDH1A1AKT1 | |
| SCHEMBL22693379 | 0.78 | PARP1 (0.51) | MKNK1PARP1CHEK1PIM1ALDH1A1 | |
| SCHEMBL12445185 | 0.78 | MAPT (0.65) | ALDH1A1SMN1; SMN2KDM4EMAPTAPEX1 | |
| SCHEMBL20440643 | 0.76 | PARP1 (0.62) | MKNK1PARP1CHEK1PIM1ALDH1A1 | |
| SCHEMBL9541195 | 0.76 | PARP1 (0.62) | MKNK1PARP1CHEK1PIM1ALDH1A1 | |
| SCHEMBL7221768 | 0.76 | PARP1 (0.62) | MKNK1PARP1CHEK1PIM1ALDH1A1 | |
| SCHEMBL164053 | 0.76 | PARP1 (0.62) | MKNK1PARP1CHEK1PIM1ALDH1A1 | |
| SCHEMBL2427721 | 0.76 | PARP1 (0.62) | MKNK1PARP1CHEK1PIM1ALDH1A1 | |
| SCHEMBL10121482 | 0.76 | PARP1 (0.62) | MKNK1PARP1CHEK1PIM1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003051898-A1 | UNUSUAL NUCLEOSIDE LIBRARIES, COMPOUNDS, AND PREFERRED USES AS ANTIVIRAL AND ANTICANCER AGENTS | RIBAPHARM INC. (US) | 2003-06-26 | — | — | WO | disclosed |
| EP-1085871-A4 | QUINAZOLINONE INHIBITORS OF cGMP PHOSPHODIESTERASE | BRISTOL MYERS SQUIBB CO (US) | 2001-10-04 | — | — | EP | disclosed |
| EP-1085871-A1 | QUINAZOLINONE INHIBITORS OF cGMP PHOSPHODIESTERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-03-28 | — | — | EP | disclosed |
| US-6087368-A | AN ENZYME INHIBITOR TREATING ERECTILE DYSFUNCTION OF SEX DISORDERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-07-11 | — | — | US | disclosed |
| WO-1999064004-A1 | QUINAZOLINONE INHIBITORS OF cGMP PHOSPHODIESTERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-12-16 | — | — | WO | disclosed |
| US-5116843-A | Anticoagulants, hypotensive agents and cardiovascular disorder | BOEHRINGER MANNHEIM GMBH (DE) | 1992-05-26 | — | — | US | disclosed |