Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 8/20 | 0.46 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7074869 | 0.93 | REN (0.44) | RENSSTR5ALDH1A1SMN1; SMN2PDE4B | |
| SCHEMBL7079908 | 0.90 | REN (0.52) | RENSSTR5PDE4B | |
| SCHEMBL7076766 | 0.90 | REN (0.54) | RENSSTR5PDE4B | |
| SCHEMBL7084760 | 0.88 | REN (0.54) | RENSSTR5ALDH1A1PDE4B | |
| SCHEMBL7084145 | 0.87 | REN (0.49) | RENSSTR5PDE4BS1PR1 | |
| SCHEMBL7079511 | 0.87 | REN (0.54) | RENPDE4B | |
| SCHEMBL6043888 | 0.87 | REN (0.49) | RENSSTR5ALDH1A1SMN1; SMN2HRH3 | |
| SCHEMBL6043894 | 0.87 | REN (0.49) | RENSSTR5ALDH1A1SMN1; SMN2HRH3 | |
| SCHEMBL7074060 | 0.87 | REN (0.48) | RENSSTR5PDE4B | |
| SCHEMBL7078446 | 0.86 | REN (0.51) | RENSSTR5PDE4BHRH3PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |