Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Silver. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.85 |
| ▸ | TSHR | P16473 | 6/20 | 0.85 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.85 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.85 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.53 |
| ▸ | CHKA | P35790 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.52 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | APP | P05067 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL65261 | 0.92 | ALDH1A1 (1.00) | ALDH1A1TSHRALOX15HSD17B10MAPK1 | |
| Hydrochloric Acid SCHEMBL379125 | 0.88 | ALDH1A1 (0.92) | ALDH1A1TSHRALOX15HSD17B10MAPK1 | |
| Hydrochloric Acid SCHEMBL379126 | 0.88 | ALDH1A1 (0.92) | ALDH1A1TSHRALOX15HSD17B10MAPK1 | |
| Hydrochloric Acid SCHEMBL2443748 | 0.88 | ALDH1A1 (0.92) | ALDH1A1TSHRALOX15HSD17B10MAPK1 | |
| Ammonia Solution, Strong SCHEMBL27868785 | 0.88 | ALDH1A1 (0.92) | ALDH1A1TSHRALOX15HSD17B10MAPK1 | |
| Hydrochloric Acid SCHEMBL7080476 | 0.85 | ALDH1A1 (0.85) | ALDH1A1TSHRALOX15HSD17B10MAPK1 | |
| SCHEMBL7076748 | 0.85 | ALDH1A1 (0.85) | ALDH1A1TSHRALOX15HSD17B10MAPK1 | |
| Hydrochloric Acid SCHEMBL21799403 | 0.85 | ALDH1A1 (0.85) | ALDH1A1TSHRALOX15HSD17B10MAPK1 | |
| SCHEMBL18134996 | 0.81 | ALDH1A1 (0.79) | ALDH1A1TSHRALOX15HSD17B10MAPK1 | |
| SCHEMBL11049310 | 0.81 | ALDH1A1 (0.79) | ALDH1A1TSHRALOX15HSD17B10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6656672-B2 | Imaging element containing incorporated photographically useful compounds | EASTMAN KODAK COMPANY | 2003-12-02 | — | — | US | disclosed |
| US-20030148233-A1 | IMAGING ELEMENT CONTAINING INCORPORATED PHOTOGRAPHICALLY USEFUL COMPOUNDS | EASTMAN KODAK COMPANY | 2003-08-07 | — | — | US | disclosed |
| EP-1324119-A1 | Imaging element containing incorporated photographically useful compounds | EASTMAN KODAK COMPANY (US) | 2003-07-02 | — | — | EP | disclosed |