Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 12/20 | 0.59 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599426 | 0.83 | CRHR1 (0.57) | CRHR1NR4A2MEN1KMT2ATP53 | |
| SCHEMBL5599396 | 0.79 | CRHR1 (0.53) | CRHR1NR4A2MEN1KMT2ATP53 | |
| SCHEMBL6094492 | 0.76 | CRHR1 (0.56) | CRHR1NR4A2MEN1KMT2ATP53 | |
| SCHEMBL5599563 | 0.75 | NR4A2 (0.50) | CRHR1NR4A2TP53 | |
| SCHEMBL5707856 | 0.74 | CRHR1 (0.46) | CRHR1NR4A2MEN1KMT2ATP53 | |
| SCHEMBL5600124 | 0.73 | CRHR1 (1.00) | CRHR1 | |
| SCHEMBL7228514 | 0.72 | CRHR1 (0.61) | CRHR1NR4A2 | |
| SCHEMBL5600109 | 0.72 | CRHR1 (0.83) | CRHR1 | |
| SCHEMBL7615502 | 0.72 | CRHR1 (0.60) | CRHR1MEN1KMT2A | |
| SCHEMBL5600092 | 0.71 | CRHR1 (0.57) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977737-B1 | CRF ANTAGONISTIC QUINO- AND QUINAZOLINES | JANSSEN PHARMACEUTICA NV (BE) | 2003-09-17 | — | — | EP | claimed |
| EP-1149583-A2 | Combinations of corticotropin releasing factor antagonists and growth hormone secretagogues | Pfizer Products Inc. (US) | 2001-10-31 | — | — | EP | claimed |