Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.42 |
| ▸ | FNTA | P49354 | 12/20 | 0.38 |
| ▸ | FNTB | P49356 | 12/20 | 0.38 |
| ▸ | PGGT1B | P53609 | 8/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7080520 | 0.95 | CYP11B1 (0.46) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| Maleic Acid SCHEMBL7077075 | 0.93 | CYP11B1 (0.42) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| Citric Acid SCHEMBL7084194 | 0.91 | CYP11B1 (0.41) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| SCHEMBL7077584 | 0.87 | CYP11B1 (0.39) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| Cadaverine Tartrate SCHEMBL7077587 | 0.86 | CYP11B1 (0.42) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| SCHEMBL7077641 | 0.85 | CYP11B1 (0.46) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| SCHEMBL7086539 | 0.85 | CYP11B1 (0.49) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| SCHEMBL7080524 | 0.84 | CYP11B1 (0.42) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| SCHEMBL7077080 | 0.83 | CYP11B1 (0.40) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| SCHEMBL7083327 | 0.81 | CYP11B1 (0.46) | CYP11B1CYP11B2FNTAFNTBPGGT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200430-A4 | THIOUREA AND ISOTHIOUREA DERIVATIVES FOR INHIBITING RAS-TRANSFORMED CELL GROWTH | YUHAN CORP LTD (KR) | 2003-01-22 | — | — | EP | disclosed |
| EP-1200430-A1 | THIOUREA AND ISOTHIOUREA DERIVATIVES FOR INHIBITING RAS-TRANSFORMED CELL GROWTH | YUHAN CORPORATION, LTD. (KR) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001009128-A1 | THIOUREA AND ISOTHIOUREA DERIVATIVES FOR INHIBITING RAS-TRANSFORMED CELL GROWTH | YUHAN CORPORATION (KR) | 2001-02-08 | — | — | WO | disclosed |