Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | KDM1A | O60341 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4267531 | 0.82 | MRGPRX4 (0.63) | MRGPRX4NPC1KDM1AMAPTL3MBTL1 | |
| SCHEMBL4431406 | 0.80 | MRGPRX4 (0.50) | MRGPRX4NPC1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL13132257 | 0.80 | MRGPRX4 (0.47) | MRGPRX4NPC1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL6041334 | 0.80 | MRGPRX4 (0.47) | MRGPRX4NPC1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL27502561 | 0.79 | MRGPRX4 (0.44) | MRGPRX4NPC1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL1128474 | 0.76 | ALOX5 (0.55) | MRGPRX4NPC1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL29754139 | 0.76 | ALOX5 (0.55) | MRGPRX4NPC1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL29568609 | 0.76 | MRGPRX4 (0.67) | MRGPRX4NPC1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL27629 | 0.76 | MRGPRX4 (0.67) | MRGPRX4NPC1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL12154961 | 0.75 | MRGPRX4 (0.48) | MRGPRX4NPC1MAPTSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |