Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.75 |
| ▸ | MEN1 | O00255 | 1/20 | 0.75 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.53 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.50 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.50 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.50 |
| ▸ | NOS3 | P29474 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.46 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7079778 | 0.99 | KMT2A (0.73) | KMT2ASMN1; SMN2MEN1TAAR1TPSAB1 | |
| SCHEMBL28218804 | 0.85 | MEN1 (0.74) | KMT2ASMN1; SMN2MEN1TAAR1TPSAB1 | |
| SCHEMBL1313894 | 0.83 | SMN1; SMN2 (0.71) | KMT2ASMN1; SMN2MEN1TAAR1TPSAB1 | |
| SCHEMBL29104598 | 0.81 | KMT2A (0.67) | KMT2ASMN1; SMN2MEN1TAAR1TPSAB1 | |
| SCHEMBL8393420 | 0.79 | MEN1 (0.61) | KMT2ASMN1; SMN2MEN1TAAR1TPSAB1 | |
| SCHEMBL8391980 | 0.78 | FKBP1A (0.72) | KMT2ATAAR1FKBP1AALDH1A1TSHR | |
| SCHEMBL8393415 | 0.77 | KMT2A (0.62) | KMT2ASMN1; SMN2MEN1TAAR1ALDH1A1 | |
| SCHEMBL17117357 | 0.77 | NAMPT (0.66) | KMT2ASMN1; SMN2MEN1TPSAB1HTT | |
| SCHEMBL17117352 | 0.77 | CA1 (0.58) | KMT2ASMN1; SMN2MEN1TPSAB1HTT | |
| SCHEMBL17117403 | 0.76 | NAMPT (0.67) | KMT2ASMN1; SMN2MEN1TPSAB1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0713483-B1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRAZENECA AB (SE) | 2003-01-15 | — | — | EP | disclosed |
| US-6030985-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 2000-02-29 | — | — | US | disclosed |
| US-5807885-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 1998-09-15 | — | — | US | disclosed |
| EP-0713483-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | Astra Aktiebolag (SE) | 1996-05-29 | — | — | EP | disclosed |
| WO-1995005363-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRA AKTIEBOLAG (SE) | 1995-02-23 | — | — | WO | disclosed |