Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7079166 | 1.00 | PRMT5 (0.48) | PRMT5KDM1ATRPV1ALOX5APFEN1 | |
| SCHEMBL1598762 | 0.85 | DPP4 (0.43) | PRMT5CYP2D6DPP4DPP8DPP9 | |
| SCHEMBL1598763 | 0.85 | DPP4 (0.43) | PRMT5CYP2D6DPP4DPP8DPP9 | |
| SCHEMBL5026513 | 0.83 | PRMT5 (0.52) | PRMT5KDM1ATRPV1ALOX5APFEN1 | |
| SCHEMBL1597673 | 0.82 | DPP4 (0.46) | CYP2D6DPP4DPP8DPP9DPP7 | |
| SCHEMBL1597671 | 0.82 | DPP4 (0.46) | CYP2D6DPP4DPP8DPP9DPP7 | |
| SCHEMBL1597674 | 0.82 | DPP4 (0.46) | CYP2D6DPP4DPP8DPP9DPP7 | |
| SCHEMBL1597799 | 0.79 | RAB9A (0.42) | HCRTR1HCRTR2 | |
| SCHEMBL1597740 | 0.79 | POLB (0.46) | HCRTR1HCRTR2 | |
| SCHEMBL1597734 | 0.79 | POLB (0.46) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003051368-A1 | N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2003-06-26 | — | — | WO | disclosed |